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10.1155/2015/161648 http://scihub22266oqcxt.onion/10.1155/2015/161648 C4668301!4668301!26665001     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26665001.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26665001|t=2015. Cracking the Code of Human Diseases Using Next-Generation Sequencing: Applications, Challenges, and Perspectives |pdf=|usr=}}{{26665001}} gab.com Text Cracking the Code of Human Diseases Using Next-Generation Sequencing: Applications, Challenges, and Perspectives JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26665001 #FOAvip Next-generation sequencing (NGS) technologies have greatly impacted on every field of molecular research mainly because they reduce costs and increase throughput of DNA sequencing. These features, together with the technology's flexibility, have opened the way to a variety of applications including the study of the molecular basis of human diseases. Several analytical approaches have been developed to selectively enrich regions of interest from the whole genome in order to identify germinal and/or somatic sequence variants and to study DNA methylation. These approaches are now widely used in research, and they are already being used in routine molecular diagnostics. However, some issues are still controversial, namely, standardization of methods, data analysis and storage, and ethical aspects. Besides providing an overview of the NGS-based approaches most frequently used to study the molecular basis of human diseases at DNA level, we discuss the principal challenges and applications of NGS in the field of human genomics. Twit Text FOAVip Cracking the Code of Human Diseases Using Next-Generation Sequencing: Applications, Challenges, and Perspectives ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26665001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26665001 #FOAvip English Wikipedia <ref>{{Cite pmid|26665001}}</ref> Cracking the Code of Human Diseases Using Next-Generation Sequencing: Applications, Challenges, and Perspectives #MMPMID26665001 Precone V; Del Monaco V; Esposito MV; De Palma FDE; Ruocco A; Salvatore F; D'Argenio V Biomed Res Int 2015[]; 2015 (ä): ä PMID26665001show ga Next-generation sequencing (NGS) technologies have greatly impacted on every field of molecular research mainly because they reduce costs and increase throughput of DNA sequencing. These features, together with the technology's flexibility, have opened the way to a variety of applications including the study of the molecular basis of human diseases. Several analytical approaches have been developed to selectively enrich regions of interest from the whole genome in order to identify germinal and/or somatic sequence variants and to study DNA methylation. These approaches are now widely used in research, and they are already being used in routine molecular diagnostics. However, some issues are still controversial, namely, standardization of methods, data analysis and storage, and ethical aspects. Besides providing an overview of the NGS-based approaches most frequently used to study the molecular basis of human diseases at DNA level, we discuss the principal challenges and applications of NGS in the field of human genomics. äCracking the Code of Human Diseases Using Next-Generation Sequencing: (epmc).pdf DeepDyve Pubget Overpricing