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2015 ; 10
(12
): e0143684
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The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid
Isomer, on Murine Peritoneal Macrophages
#MMPMID26629697
Liu WN
; Leung KN
PLoS One
2015[]; 10
(12
): e0143684
PMID26629697
show ga
This study aims at demonstrating the immunomodulatory property of jacaric acid, a
conjugated linolenic acid (CLNA) isomer that is present in jacaranda seed oil, on
murine peritoneal macrophages. Our results showed that jacaric acid exhibited no
significant cytotoxicity on the thioglycollate-elicited murine peritoneal
macrophages as revealed by the neutral red uptake assay, but markedly increased
their cytostatic activity on the T-cell lymphoma MBL-2 cells as measured by the
fluorometric CyQuant® NF Cell Proliferation Assay Kit. Flow cytometric analysis
indicated that jacaric acid could enhance the endocytic activity of macrophages
and elevated their intracellular production of superoxide anion. Moreover,
jacaric acid-treated macrophages showed an increase in the production of nitric
oxide which was accompanied by an increase in the expression level of inducible
nitric oxide synthase protein. In addition, the secretion of several
pro-inflammatory cytokines, including interferon-?, interleukin-1? and tumor
necrosis factor-?, was up-regulated. Collectively, our results indicated that the
naturally-occurring CLNA isomer, jacaric acid, could exhibit immunomodulating
activity on the murine peritoneal macrophages in vitro, suggesting that this CLNA
isomer may act as an immunopotentiator which can be exploited for the treatment
of some immunological disorders with minimal toxicity and fewer side effects.