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2015 ; 110
(5
): 510
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gab.com Text
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English Wikipedia
Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling,
accelerators and brakes
#MMPMID26318600
Andreadou I
; Iliodromitis EK
; Szabo C
; Papapetropoulos A
Basic Res Cardiol
2015[Sep]; 110
(5
): 510
PMID26318600
show ga
Over the past decade, hydrogen sulfide has emerged as an important
cardioprotective molecule with potential for clinical applications. Although
several pathways have been proposed to mediate the beneficial effects of H2S, the
NO/cGMP axis has attracted significant attention. Recent evidence has suggested
that cGMP-dependent protein kinase can lie both downstream and upstream of H2S.
The current literature on this topic is reviewed and data from recent studies are
integrated to propose a unifying model.
|Animals
[MESH]
|Cyclic GMP-Dependent Protein Kinases/*metabolism
[MESH]