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10.1038/ncomms9823 http://scihub22266oqcxt.onion/10.1038/ncomms9823 C4667618!4667618!26549758     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26549758|t=2015. Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2 |pdf=|usr=}}{{26549758}} gab.com Text Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26549758 #FOAvip T-cell development is accompanied by epigenetic changes that ensure the silencing of stem cell-related genes and the activation of lymphocyte-specific programmes. How transcription factors influence these changes remains unclear. We show that the Ikaros transcription factor forms a complex with Polycomb repressive complex 2 (PRC2) in CD4?CD8? thymocytes and allows its binding to more than 500 developmentally regulated loci, including those normally activated in haematopoietic stem cells and others induced by the Notch pathway. Loss of Ikaros in CD4?CD8? cells leads to reduced histone H3 lysine 27 trimethylation and ectopic gene expression. Furthermore, Ikaros binding triggers PRC2 recruitment and Ikaros interacts with PRC2 independently of the nucleosome remodelling and deacetylation complex. Our results identify Ikaros as a fundamental regulator of PRC2 function in developing T cells. Twit Text FOAVip Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26549758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26549758 #FOAvip English Wikipedia <ref>{{Cite pmid|26549758}}</ref> Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2 #MMPMID26549758 Oravecz A; Apostolov A; Polak K; Jost B; Le Gras S; Chan S; Kastner P Nat Commun 2015[]; 6 (ä): ä PMID26549758show ga T-cell development is accompanied by epigenetic changes that ensure the silencing of stem cell-related genes and the activation of lymphocyte-specific programmes. How transcription factors influence these changes remains unclear. We show that the Ikaros transcription factor forms a complex with Polycomb repressive complex 2 (PRC2) in CD4?CD8? thymocytes and allows its binding to more than 500 developmentally regulated loci, including those normally activated in haematopoietic stem cells and others induced by the Notch pathway. Loss of Ikaros in CD4?CD8? cells leads to reduced histone H3 lysine 27 trimethylation and ectopic gene expression. Furthermore, Ikaros binding triggers PRC2 recruitment and Ikaros interacts with PRC2 independently of the nucleosome remodelling and deacetylation complex. Our results identify Ikaros as a fundamental regulator of PRC2 function in developing T cells. äIkaros mediates gene silencing in T cells through Polycomb repressive (epmc).pdf DeepDyve Pubget Overpricing