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10.1002/pds.3249 http://scihub22266oqcxt.onion/10.1002/pds.3249 C4667555!4667555!22431419     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacoepidemiol+Drug+Saf 2012 ; 21 (5): 515-23 Nephropedia Template TP {{tp|p=22431419|t=2012. Initiation of sulfonylureas versus metformin is associated with higher blood pressure at one year |pdf=|usr=}}{{22431419}} gab.com Text Initiation of sulfonylureas versus metformin is associated with higher blood pressure at one year JO: Pharmacoepidemiol Drug Saf http://www.kidney.de/pget.php?&tw=1&pmid=22431419 #FOAvip Purpose: To determine if incident oral antidiabetic drugs (OAD) use was associated with 12-month systolic blood pressure (BP) and if this was mediated through body mass index (BMI) changes. Methods: A retrospective cohort of veterans with hypertension who initiated metformin (n=2057) or sulfonylurea (n=1494) between January 1, 2000 and December 31, 2007 in the Veterans Administration Mid-South Network was assembled. Patients were included if they had complete covariates, including 12 month BP and BMI, and persisted on therapy for 12 months. Linear regression was conducted to investigate the effect of OADs on 12-month systolic BP adjusting for demographics, glycated hemoglobin, creatinine, body mass index, healthcare utilization and co-morbidities including cardiovascular disease. A second analysis examined if these effects were mediated by BMI change. The secondary outcome was the proportion of patients who had a controlled BP (?140/90 mmHg) at 12 months adjusted for baseline BP and covariates. Results: Patients were white (82%) males (97%) with median age of 64 years (Interquartile range [IQR] 57, 72) and 27% had history of CVD. Sulfonylurea users had a 1.33 mmHg [0.16, 2.50 p=0.03] higher 12-month systolic BP than metformin users. The median change in BMI from OAD initiation to 12 months was ?0.76 (IQR ?1.78, 0.07) and 0.21 (IQR ?0.57, 1.03) among metformin and sulfonylurea users, respectively. In a model adjusting for BMI change, the difference in 12-month systolic BP between sulfonylurea and metformin users became insignificant [0.23 (?1.00, 1.45) p=0.72], while one BMI unit change was associated with an increase in 12-month systolic BP of 1.07 mmHg (0.74, 1.40 p<0.0001). At 12 months 68.3% of metformin patients had controlled BP versus 64.2% of sulfonylurea patients (p=0.01). Conclusions: Compared with metformin, sulfonylurea initiation was associated with increased systolic BP at 12 months which appears to be mediated by the differential effects of these drugs on BMI. Twit Text FOAVip Initiation of sulfonylureas versus metformin is associated with higher blood pressure at one year ????Pharmacoepidemiol Drug Saf http://www.kidney.de/pget.php?&tw=1&pmid=22431419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22431419 #FOAvip English Wikipedia <ref>{{Cite pmid|22431419}}</ref> Initiation of sulfonylureas versus metformin is associated with higher blood pressure at one year #MMPMID22431419 Roumie CL; Liu X; Choma NN; Greevy RA; Hung AM; Grijalva CG; Griffin MR Pharmacoepidemiol Drug Saf 2012[May]; 21 (5): 515-23 PMID22431419show ga Purpose: To determine if incident oral antidiabetic drugs (OAD) use was associated with 12-month systolic blood pressure (BP) and if this was mediated through body mass index (BMI) changes. Methods: A retrospective cohort of veterans with hypertension who initiated metformin (n=2057) or sulfonylurea (n=1494) between January 1, 2000 and December 31, 2007 in the Veterans Administration Mid-South Network was assembled. Patients were included if they had complete covariates, including 12 month BP and BMI, and persisted on therapy for 12 months. Linear regression was conducted to investigate the effect of OADs on 12-month systolic BP adjusting for demographics, glycated hemoglobin, creatinine, body mass index, healthcare utilization and co-morbidities including cardiovascular disease. A second analysis examined if these effects were mediated by BMI change. The secondary outcome was the proportion of patients who had a controlled BP (?140/90 mmHg) at 12 months adjusted for baseline BP and covariates. Results: Patients were white (82%) males (97%) with median age of 64 years (Interquartile range [IQR] 57, 72) and 27% had history of CVD. Sulfonylurea users had a 1.33 mmHg [0.16, 2.50 p=0.03] higher 12-month systolic BP than metformin users. The median change in BMI from OAD initiation to 12 months was ?0.76 (IQR ?1.78, 0.07) and 0.21 (IQR ?0.57, 1.03) among metformin and sulfonylurea users, respectively. In a model adjusting for BMI change, the difference in 12-month systolic BP between sulfonylurea and metformin users became insignificant [0.23 (?1.00, 1.45) p=0.72], while one BMI unit change was associated with an increase in 12-month systolic BP of 1.07 mmHg (0.74, 1.40 p<0.0001). At 12 months 68.3% of metformin patients had controlled BP versus 64.2% of sulfonylurea patients (p=0.01). Conclusions: Compared with metformin, sulfonylurea initiation was associated with increased systolic BP at 12 months which appears to be mediated by the differential effects of these drugs on BMI. äInitiation of sulfonylureas versus metformin is associated with higher(epmc).pdf DeepDyve Pubget Overpricing