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10.1038/srep17311 http://scihub22266oqcxt.onion/10.1038/srep17311 C4667293!4667293!26626153     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26626153|t=2015. High Frequency of Imprinted Methylation Errors in Human Preimplantation Embryos |pdf=|usr=}}{{26626153}} gab.com Text High Frequency of Imprinted Methylation Errors in Human Preimplantation Embryos JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26626153 #FOAvip Assisted reproductive technologies (ARTs) represent the best chance for infertile couples to conceive, although increased risks for morbidities exist, including imprinting disorders. This increased risk could arise from ARTs disrupting genomic imprints during gametogenesis or preimplantation. The few studies examining ART effects on genomic imprinting primarily assessed poor quality human embryos. Here, we examined day 3 and blastocyst stage, good to high quality, donated human embryos for imprinted SNRPN, KCNQ1OT1 and H19 methylation. Seventy-six percent day 3 embryos and 50% blastocysts exhibited perturbed imprinted methylation, demonstrating that extended culture did not pose greater risk for imprinting errors than short culture. Comparison of embryos with normal and abnormal methylation didn?t reveal any confounding factors. Notably, two embryos from male factor infertility patients using donor sperm harboured aberrant methylation, suggesting errors in these embryos cannot be explained by infertility alone. Overall, these results indicate that ART human preimplantation embryos possess a high frequency of imprinted methylation errors. Twit Text FOAVip High Frequency of Imprinted Methylation Errors in Human Preimplantation Embryos ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26626153 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26626153 #FOAvip English Wikipedia <ref>{{Cite pmid|26626153}}</ref> High Frequency of Imprinted Methylation Errors in Human Preimplantation Embryos #MMPMID26626153 White CR; Denomme MM; Tekpetey FR; Feyles V; Power SGA; Mann MRW Sci Rep 2015[]; 5 (ä): ä PMID26626153show ga Assisted reproductive technologies (ARTs) represent the best chance for infertile couples to conceive, although increased risks for morbidities exist, including imprinting disorders. This increased risk could arise from ARTs disrupting genomic imprints during gametogenesis or preimplantation. The few studies examining ART effects on genomic imprinting primarily assessed poor quality human embryos. Here, we examined day 3 and blastocyst stage, good to high quality, donated human embryos for imprinted SNRPN, KCNQ1OT1 and H19 methylation. Seventy-six percent day 3 embryos and 50% blastocysts exhibited perturbed imprinted methylation, demonstrating that extended culture did not pose greater risk for imprinting errors than short culture. Comparison of embryos with normal and abnormal methylation didn?t reveal any confounding factors. Notably, two embryos from male factor infertility patients using donor sperm harboured aberrant methylation, suggesting errors in these embryos cannot be explained by infertility alone. Overall, these results indicate that ART human preimplantation embryos possess a high frequency of imprinted methylation errors. äHigh Frequency of Imprinted Methylation Errors in Human Preimplantatio(epmc).pdf DeepDyve Pubget Overpricing