Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26627982
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Rep
2015 ; 5
(ä): 17654
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The effectiveness of Corticosteroids on mortality in patients with acute
respiratory distress syndrome or acute lung injury: a secondary analysis
#MMPMID26627982
Zhang Z
; Chen L
; Ni H
Sci Rep
2015[Dec]; 5
(ä): 17654
PMID26627982
show ga
The development of acute respiratory distress syndrome (ARDS) is associated with
dys-regulated inflammation. Since corticosteroids are potent anti-inflammatory
drugs, they are thought to be beneficial for ARDS patients. The study aimed to
investigate the effectiveness of corticosteroids on mortality outcome in ARDS
patients. The study was a secondary analysis of a prospective randomized
controlled trial (NCT00979121). ARDS patients with invasive mechanical
ventilation were enrolled. Corticosteroids use was defined as IV or PO
administration of corticosteroids totaling more than 20?mg methylprednisolone
equivalents during one calendar day. Missing data were handled using multiple
imputation technique. Multivariable model was built to adjust for confounding
covariates. A total of 745 patients were enrolled, including 540 survivors and
205 non-survivors. Patients in the non-survivor group were more likely to use
corticosteroids (38% vs. 29.8%; p?=?0.032). After adjustment for other potential
confounders, corticosteroids showed no statistically significant effect on
mortality outcome (OR: 1.18; 95% CI: 0.81-1.71). Furthermore, we investigated the
interaction between corticosteroid use and variables of vasopressor and PaO2. The
result showed that there was no significant interaction. In conclusion, the study
failed to identify any beneficial effects of corticosteroids on mortality outcome
in patients with ARDS.