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10.1038/srep17638 http://scihub22266oqcxt.onion/10.1038/srep17638 C4667265!4667265!26627341     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26627341|t=2015. Preventive effects of vitamin D treatment on bleomycin-induced pulmonary fibrosis |pdf=|usr=}}{{26627341}} gab.com Text Preventive effects of vitamin D treatment on bleomycin-induced pulmonary fibrosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26627341 #FOAvip Patients with pulmonary fibrosis often have low vitamin D levels, the effects of which are largely unknown. We here report that early vitamin D supplementation significantly reduced the severity of pulmonary fibrosis and inflammatory cell accumulationin in the bleomycin-induced pulmonary fibrosis mouse model on supplementary days 14, 21 and 28 (P?<?0.001). Vitamin D supplementation also prevented some ultrastructural changes in response to bleomycin administration, including basement membrane thickening, interstitial fibrin deposition and microvilli flattening or disappearance on days 14, 21 and 28, and lamellar body swelling or vacuolation on days 21 and 28. The bleomycin group had rising hydroxyproline level on days 14, 21 and 28, whereas the vitamin D treatment group showed consistently lower hydroxyproline level but still higher than that of the control group (P?<?0.001). Our immunohistochemistry and densitometry analyses showed less staining for ?-smooth muscle actin, a myofibroblast marker, in the vitamin D group compared to the bleomycin group (P?<?0.001). Thus, vitamin D treatment could prevent bleomycin-induced pulmonary fibrosis by delaying or suppressing ultrastructural changes, as well as attenuating hydroxyproline accumulation and inhibiting myofibroblastic proliferation. These data further our understanding of the roles of vitamin D in pulmonary fibrogenesis and in the treatment of pulmonary fibrosis. Twit Text FOAVip Preventive effects of vitamin D treatment on bleomycin-induced pulmonary fibrosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26627341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26627341 #FOAvip English Wikipedia <ref>{{Cite pmid|26627341}}</ref> Preventive effects of vitamin D treatment on bleomycin-induced pulmonary fibrosis #MMPMID26627341 Zhang Z; Yu X; Fang X; Liang A; Yu Z; Gu P; Zeng Y; He J; Zhu H; Li S; Fan D; Han F; Zhang L; Yi X Sci Rep 2015[]; 5 (ä): ä PMID26627341show ga Patients with pulmonary fibrosis often have low vitamin D levels, the effects of which are largely unknown. We here report that early vitamin D supplementation significantly reduced the severity of pulmonary fibrosis and inflammatory cell accumulationin in the bleomycin-induced pulmonary fibrosis mouse model on supplementary days 14, 21 and 28 (P? äPreventive effects of vitamin D treatment on bleomycin-induced pulmona(epmc).pdf DeepDyve Pubget Overpricing