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10.1155/2015/250530

http://scihub22266oqcxt.onion/10.1155/2015/250530
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C4667022!4667022!26664405
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suck abstract from ncbi


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pmid26664405      Case+Rep+Med 2015 ; 2015 (ä): ä
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  • Allergic Interstitial Nephritis Manifesting as a Striated Nephrogram #MMPMID26664405
  • Moinuddin I; Bracamonte E; Thajudeen B; Sussman A; Madhrira M; Costello J
  • Case Rep Med 2015[]; 2015 (ä): ä PMID26664405show ga
  • Allergic interstitial nephritis (AIN) is an underdiagnosed cause of acute kidney injury (AKI). Guidelines suggest that AIN should be suspected in a patient who presents with an elevated serum creatinine and a urinalysis that shows white cells, white cell casts, or eosinophiluria. Drug-induced AIN is suspected if AKI is temporally related to the initiation of a new drug. However, patients with bland sediment and normal urinalysis can also have AIN. Currently, a definitive diagnosis of AIN is made by renal biopsy which is invasive and fraught with risks such as bleeding, infection, and hematoma. Additionally, it is frequently unclear when a kidney biopsy should be undertaken. We describe a biopsy proven case of allergic interstitial nephritis which manifested on contrast enhanced Magnetic Resonance Imaging (MRI) as a striated nephrogram. Newer and more stable macrocyclic gadolinium contrast agents have a well-demonstrated safety profile. Additionally, in the presentation of AKI, gadolinium contrast agents are safe to administer in patients who demonstrate good urine output and a downtrending creatinine. We propose that the differential for a striated nephrogram may include AIN. In cases in which the suspicion for AIN is high, this diagnostic consideration may be further characterized by contrast enhanced MRI.
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