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10.1152/ajpheart.00339.2015

http://scihub22266oqcxt.onion/10.1152/ajpheart.00339.2015
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C4666985!4666985!26432840
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suck abstract from ncbi


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pmid26432840      Am+J+Physiol+Heart+Circ+Physiol 2015 ; 309 (10): H1720-30
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  • N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy #MMPMID26432840
  • Wilder T; Ryba DM; Wieczorek DF; Wolska BM; Solaro RJ
  • Am J Physiol Heart Circ Physiol 2015[Nov]; 309 (10): H1720-30 PMID26432840show ga
  • Novel findings include reversal of established hypertrophy, left atrial dilation, and diastolic dysfunction in a model of HCM treated with the antioxidant N-acetylcysteine. This was associated with a reduction in S-glutathionylation of myofilament proteins, which was increased in untreated controls, a decrease in myofilament Ca2+response, and hastening of cross-bridge kinetics.
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