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10.1038/onc.2015.174 http://scihub22266oqcxt.onion/10.1038/onc.2015.174 C4666810!4666810!26028034     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2016 ; 35 (9): 1090-8 Nephropedia Template TP {{tp|p=26028034|t=2016. Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets |pdf=|usr=}}{{26028034}} gab.com Text Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26028034 #FOAvip HOXA9 is a homeodomain-containing transcription factor that plays an important role in hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A variety of upstream genetic alterations in acute myeloid leukemia (AML) lead to overexpression of HOXA9, which is a strong predictor of poor prognosis. In many cases, HOXA9 has been shown to be necessary for maintaining leukemic transformation, however the molecular mechanisms through which it promotes leukemogenesis remain elusive. Recent work has established that HOXA9 regulates downstream gene expression through binding at promoter distal enhancers along with a subset of cell-specific cofactor and collaborator proteins. Increasing efforts are being made to identify both the critical cofactors and target genes required for maintaining transformation in HOXA9-overexpressing leukemias. With continued advances in understanding HOXA9-mediated transformation, there is a wealth of opportunity for developing novel therapeutics that would be applicable for the greater than 50% of AML with overexpression of HOXA9. Twit Text FOAVip Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26028034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26028034 #FOAvip English Wikipedia <ref>{{Cite pmid|26028034}}</ref> Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets #MMPMID26028034 Collins CT; Hess JL Oncogene 2016[Mar]; 35 (9): 1090-8 PMID26028034show ga HOXA9 is a homeodomain-containing transcription factor that plays an important role in hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A variety of upstream genetic alterations in acute myeloid leukemia (AML) lead to overexpression of HOXA9, which is a strong predictor of poor prognosis. In many cases, HOXA9 has been shown to be necessary for maintaining leukemic transformation, however the molecular mechanisms through which it promotes leukemogenesis remain elusive. Recent work has established that HOXA9 regulates downstream gene expression through binding at promoter distal enhancers along with a subset of cell-specific cofactor and collaborator proteins. Increasing efforts are being made to identify both the critical cofactors and target genes required for maintaining transformation in HOXA9-overexpressing leukemias. With continued advances in understanding HOXA9-mediated transformation, there is a wealth of opportunity for developing novel therapeutics that would be applicable for the greater than 50% of AML with overexpression of HOXA9. äRole of HOXA9 in leukemia: dysregulation, cofactors and essential targ(epmc).pdf DeepDyve Pubget Overpricing