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2015 ; 10
(12
): e0143542
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Improved Classification of Lung Cancer Using Radial Basis Function Neural Network
with Affine Transforms of Voss Representation
#MMPMID26625358
Adetiba E
; Olugbara OO
PLoS One
2015[]; 10
(12
): e0143542
PMID26625358
show ga
Lung cancer is one of the diseases responsible for a large number of cancer
related death cases worldwide. The recommended standard for screening and early
detection of lung cancer is the low dose computed tomography. However, many
patients diagnosed die within one year, which makes it essential to find
alternative approaches for screening and early detection of lung cancer. We
present computational methods that can be implemented in a functional
multi-genomic system for classification, screening and early detection of lung
cancer victims. Samples of top ten biomarker genes previously reported to have
the highest frequency of lung cancer mutations and sequences of normal biomarker
genes were respectively collected from the COSMIC and NCBI databases to validate
the computational methods. Experiments were performed based on the combinations
of Z-curve and tetrahedron affine transforms, Histogram of Oriented Gradient
(HOG), Multilayer perceptron and Gaussian Radial Basis Function (RBF) neural
networks to obtain an appropriate combination of computational methods to achieve
improved classification of lung cancer biomarker genes. Results show that a
combination of affine transforms of Voss representation, HOG genomic features and
Gaussian RBF neural network perceptibly improves classification accuracy,
specificity and sensitivity of lung cancer biomarker genes as well as achieving
low mean square error.