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10.1093/nar/gkv1136 http://scihub22266oqcxt.onion/10.1093/nar/gkv1136 C4666366!4666366!26519467     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2015 ; 43 (21): 10083-101 Nephropedia Template TP {{tp|p=26519467|t=2015. The current state of eukaryotic DNA base damage and repair |pdf=|usr=}}{{26519467}} gab.com Text The current state of eukaryotic DNA base damage and repair JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26519467 #FOAvip DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar, and single-strand break damage resulting from oxidation, alkylation, deamination, and spontaneous hydrolysis. If left unrepaired, such lesions can become fixed in the genome as permanent mutations. Thus, evolution has led to the creation of several highly conserved, partially redundant pathways to repair or mitigate the effects of DNA base damage. The biochemical mechanisms of these pathways have been well characterized and the impact of this work was recently highlighted by the selection of Tomas Lindahl, Aziz Sancar and Paul Modrich as the recipients of the 2015 Nobel Prize in Chemistry for their seminal work in defining DNA repair pathways. However, how these repair pathways are regulated and interconnected is still being elucidated. This review focuses on the classical base excision repair and strand incision pathways in eukaryotes, considering both Saccharomyces cerevisiae and humans, and extends to some important questions and challenges facing the field of DNA base damage repair. Twit Text FOAVip The current state of eukaryotic DNA base damage and repair ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26519467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26519467 #FOAvip English Wikipedia <ref>{{Cite pmid|26519467}}</ref> The current state of eukaryotic DNA base damage and repair #MMPMID26519467 Bauer NC; Corbett AH; Doetsch PW Nucleic Acids Res 2015[Dec]; 43 (21): 10083-101 PMID26519467show ga DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar, and single-strand break damage resulting from oxidation, alkylation, deamination, and spontaneous hydrolysis. If left unrepaired, such lesions can become fixed in the genome as permanent mutations. Thus, evolution has led to the creation of several highly conserved, partially redundant pathways to repair or mitigate the effects of DNA base damage. The biochemical mechanisms of these pathways have been well characterized and the impact of this work was recently highlighted by the selection of Tomas Lindahl, Aziz Sancar and Paul Modrich as the recipients of the 2015 Nobel Prize in Chemistry for their seminal work in defining DNA repair pathways. However, how these repair pathways are regulated and interconnected is still being elucidated. This review focuses on the classical base excision repair and strand incision pathways in eukaryotes, considering both Saccharomyces cerevisiae and humans, and extends to some important questions and challenges facing the field of DNA base damage repair. äThe current state of eukaryotic DNA base damage and repair (epmc).pdf DeepDyve Pubget Overpricing