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10.1007/s00330-015-3809-x

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suck abstract from ncbi


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pmid25991481      Eur+Radiol 2016 ; 26 (1): 271-7
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  • High resolution pituitary gland MRI at 7 0 tesla: a clinical evaluation in Cushing?s disease #MMPMID25991481
  • de Rotte AAJ; Groenewegen A; Rutgers DR; Witkamp T; Zelissen PMJ; Meijer FJA; van Lindert EJ; Hermus A; Luijten PR; Hendrikse J
  • Eur Radiol 2016[]; 26 (1): 271-7 PMID25991481show ga
  • Objective: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing?s disease. Methods: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients. Results: The interobserver agreement for lesion detection was good at 1.5 T MRI (??=?0.69) and 7.0 T MRI (??=?0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI. Conclusion: The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing?s disease was good, and lesions were detected more accurately with 7.0 T MRI. Key Points: ? Interobserver agreement for lesion detection on 1.5 T MRI was good;? Interobserver agreement for lesion detection on 7.0 T MRI was good;? 7.0 T enabled confirmation of unclear lesions at 1.5 T;? 7.0 T enabled visualization of lesions not visible at 1.5 T. Electronic supplementary material: The online version of this article (doi:10.1007/s00330-015-3809-x) contains supplementary material, which is available to authorized users.
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