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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Nephrol
2015 ; 16
(ä): 196
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The chronic kidney disease epidemiology collaboration equation combining
creatinine and cystatin C accurately assesses renal function in patients with
cirrhosis
#MMPMID26627205
Krones E
; Fickert P
; Zitta S
; Neunherz S
; Artinger K
; Reibnegger G
; Durchschein F
; Wagner D
; Stojakovic T
; Stadlbauer V
; Fauler G
; Stauber R
; Zollner G
; Kniepeiss D
; Rosenkranz AR
BMC Nephrol
2015[Dec]; 16
(ä): 196
PMID26627205
show ga
BACKGROUND: Accurate measurement of renal function in cirrhotic patients is still
challenging. To find the best test for the determination of the true glomerular
filtration rate (GFR) in cirrhotic patients this study prospectively compared
measured (m)GFR, the gold standard, with estimated (e)GFR using equations based
on serum levels of creatinine and cystatin C. METHODS: GFR was measured by
sinistrin clearance using the bolus method in 50 patients with cirrhosis (Child
Turcotte Pugh score A, B and C) and 24 age-matched healthy subjects as controls.
Measured (m)GFR was compared to eGFR using bias, accuracy 10 % and 30 %, as well
as correlation coefficients. RESULTS: Creatinine-based equations generally
overestimated GFR in patients with cirrhosis and showed a bias (average
difference between mGFR and eGFR) of -40 (CG), -12 (MDRD) and -9 (CKD-EPI-Cr)
ml/min/1.73 m(2). Cystatin C-based equations underestimated GFR, especially in
patients with Child Turcotte Pugh score C (bias 17 ml/min/1.73 m(2)for
CKD-EPI-CysC). Of these equations, the CKD-EPI equation that combines creatinine
and cystatin C (CKD-EPI-Cr-CysC) showed a bias of 0.12 ml/min/1.73 m(2) as
compared to measured GFR. CONCLUSIONS: The CKD-EPI equation that combines serum
creatinine and cystatin C measurements shows the best performance for accurate
estimation of GFR in cirrhosis, especially at advanced stages.