Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26640574
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Analysis of the correlation between serum resistin and the variability of
erythropoietin responsiveness in patients with chronic kidney disease
#MMPMID26640574
Zhang H
; Li X
; Kan Y
; Yang F
; Hou Y
; DU Y
Exp Ther Med
2015[Nov]; 10
(5
): 1925-1930
PMID26640574
show ga
Chronic kidney disease (CKD) is commonly accompanied by inflammation and anemia;
however, the pathogenesis of CKD is unclear. Expression of resistin, a
cysteine-rich secretory plasma protein, is correlated with the expression of
tumor necrosis factor (TNF)-?, interleukin (IL)-6 and lipoprotein-associated
phospholipase A2, indicating that resistin may be involved in inflammatory
events. In addition, inflammation inhibits the activity of erythropoietin (EPO)
and, thus, erythropoiesis. The aim of the present study was to analyze the
correlation between serum resistin and the variability of EPO responsiveness in
CKD patients. The levels of serum creatinine (SCr), C-reactive protein (CRP),
total cholesterol, triglycerides, IL-6 and serum resistin were measured in the
samples obtained from 138 CKD patients and healthy control subjects. The levels
of serum resistin in the CKD groups with and without hemodialysis were
significantly higher than those observed in the normal control group (P<0.01) and
the levels of serum resistin in the hemodialysis CKD group were higher than those
observed in the CKD group without dialysis (P<0.01). The levels of serum resistin
in patients in the randomly selected CKD group (with hemodialysis) were
positively correlated with the duration of dialysis and the levels of SCr and CRP
(P<0.05), however, were negatively correlated with the estimated glomerular
filtration rate. The EPO resistance index (ERI) was identified to be associated
with body mass index and the levels of CRP and resistin; furthermore, EPO
reactivity was correlated with the level of resistin and ERI. The levels of serum
resistin were correlated with the variability in EPO responsiveness that was
observed in the CKD patients. Therefore, the measurement of serum resistin may
aid with understanding the mechanisms, clinical diagnosis and treatment of CKD.
free
free
free
