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10.1038/srep17618 http://scihub22266oqcxt.onion/10.1038/srep17618 C4664936!4664936 !26620926     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26620926 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 17618 Nephropedia Template TP {{tp|p=26620926 |t=2015. MiR-181b regulates cisplatin chemosensitivity and metastasis by targeting TGF?R1/Smad signaling pathway in NSCLC |pdf=|usr=}}{{26620926 }} gab.com Text MiR-181b regulates cisplatin chemosensitivity and metastasis by targeting TGF R1/Smad signaling pathway in NSCLC JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26620926 #FOAvip MicroRNAs (miRNAs) have been identified as important post-transcriptional regulators involved in various biological and pathological processes of cells, but their underlying mechanisms in chemosensitivity and metastasis have not been fully elucidated. The objective of this study was to identify miR-181b and its mechanism in the chemosensitivity and metastasis of NSCLC. We found that miR-181b expression levels were lower in A549/DDP cells compared with A549 cells. Functional assays showed that the overexpression of miR-181b inhibited proliferation, enhanced chemosensitivity to DDP, attenuated migration and metastatic ability in NSCLC cell lines in vitro and in vivo. TGF?R1 was subsequently identified as a novel functional target of miR-181b. TGF?R1 knockdown revealed similar effects as that of ectopic miR-181b expression, whereas overexpression of TGF?R1 rescued the function of miR-181b-mediated growth, chemosensitivity and metastasis in NSCLC cells. In addition, miR-181b could inactivate the TGF?R1/Smad signaling pathway. We also observed that decreased miR-181b expression and increased TGF?R1 expression were significantly associated with chemosensitivity to DDP and tumor metastasis in NSCLC patients. Consequently, miR-181b functions as a tumor suppressor and has an important role in proliferation, chemosensitivity to DDP and metastasis of NSCLC by targeting TGF?R1/Smad signaling pathway. Twit Text FOAVip MiR-181b regulates cisplatin chemosensitivity and metastasis by targeting TGF R1/Smad signaling pathway in NSCLC ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26620926 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26620926 #FOAvip English Wikipedia <ref>{{Cite pmid|26620926 }}</ref> MiR-181b regulates cisplatin chemosensitivity and metastasis by targeting TGF?R1/Smad signaling pathway in NSCLC #MMPMID26620926 Wang X ; Chen X ; Meng Q ; Jing H ; Lu H ; Yang Y ; Cai L ; Zhao Y Sci Rep 2015[Dec]; 5 (ä): 17618 PMID26620926 show ga MicroRNAs (miRNAs) have been identified as important post-transcriptional regulators involved in various biological and pathological processes of cells, but their underlying mechanisms in chemosensitivity and metastasis have not been fully elucidated. The objective of this study was to identify miR-181b and its mechanism in the chemosensitivity and metastasis of NSCLC. We found that miR-181b expression levels were lower in A549/DDP cells compared with A549 cells. Functional assays showed that the overexpression of miR-181b inhibited proliferation, enhanced chemosensitivity to DDP, attenuated migration and metastatic ability in NSCLC cell lines in vitro and in vivo. TGF?R1 was subsequently identified as a novel functional target of miR-181b. TGF?R1 knockdown revealed similar effects as that of ectopic miR-181b expression, whereas overexpression of TGF?R1 rescued the function of miR-181b-mediated growth, chemosensitivity and metastasis in NSCLC cells. In addition, miR-181b could inactivate the TGF?R1/Smad signaling pathway. We also observed that decreased miR-181b expression and increased TGF?R1 expression were significantly associated with chemosensitivity to DDP and tumor metastasis in NSCLC patients. Consequently, miR-181b functions as a tumor suppressor and has an important role in proliferation, chemosensitivity to DDP and metastasis of NSCLC by targeting TGF?R1/Smad signaling pathway. |Carcinoma, Non-Small-Cell Lung/drug therapy/genetics/*metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cisplatin/*pharmacology [MESH] |Drug Resistance, Neoplasm/*drug effects/genetics [MESH] |Gene Expression Regulation, Neoplastic/*drug effects/genetics [MESH] |Humans [MESH] |Lung Neoplasms/drug therapy/genetics/*metabolism/pathology [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH] |RNA, Neoplasm/genetics/*metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/genetics/*metabolism [MESH] |Signal Transduction/*drug effects/genetics [MESH]MiR-181b regulates cisplatin chemosensitivity and metastasis by target(epmc).pdf DeepDyve Pubget Overpricing