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10.1038/srep17625 http://scihub22266oqcxt.onion/10.1038/srep17625 C4664933!4664933!26621077     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26621077|t=2015. Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson?s disease patients |pdf=|usr=}}{{26621077}} gab.com Text Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson s disease patients JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26621077 #FOAvip Lewy bodies (LBs), which mainly consist of ?-synuclein (?-syn), are neuropathological hallmarks of patients with Parkinson?s disease (PD). The fine structure of LBs is unknown, and LBs cannot be made artificially. Nevertheless, many studies have described fibrillisation using recombinant ?-syn purified from E. coli. An extremely fundamental problem is whether the structure of LBs is the same as that of recombinant amyloid fibrils. Thus, we used synchrotron Fourier transform infrared micro-spectroscopy (FTIRM) to analyse the fine structure of LBs in the brain of PD patients. Our results showed a shift in the infrared spectrum that indicates abundance of a ?-sheet-rich structure in LBs. Also, 2D infrared mapping of LBs revealed that the content of the ?-sheet structure is higher in the halo than in the core, and the core contains a large amount of proteins and lipids. Twit Text FOAVip Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson s disease patients ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26621077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26621077 #FOAvip English Wikipedia <ref>{{Cite pmid|26621077}}</ref> Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson?s disease patients #MMPMID26621077 Araki K; Yagi N; Ikemoto Y; Yagi H; Choong CJ; Hayakawa H; Beck G; Sumi H; Fujimura H; Moriwaki T; Nagai Y; Goto Y; Mochizuki H Sci Rep 2015[]; 5 (ä): ä PMID26621077show ga Lewy bodies (LBs), which mainly consist of ?-synuclein (?-syn), are neuropathological hallmarks of patients with Parkinson?s disease (PD). The fine structure of LBs is unknown, and LBs cannot be made artificially. Nevertheless, many studies have described fibrillisation using recombinant ?-syn purified from E. coli. An extremely fundamental problem is whether the structure of LBs is the same as that of recombinant amyloid fibrils. Thus, we used synchrotron Fourier transform infrared micro-spectroscopy (FTIRM) to analyse the fine structure of LBs in the brain of PD patients. Our results showed a shift in the infrared spectrum that indicates abundance of a ?-sheet-rich structure in LBs. Also, 2D infrared mapping of LBs revealed that the content of the ?-sheet structure is higher in the halo than in the core, and the core contains a large amount of proteins and lipids. äSynchrotron FTIR micro-spectroscopy for structural analysis of Lewy bo(epmc).pdf DeepDyve Pubget Overpricing