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2015 ; 5
(ä): 17625
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Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the
brain of Parkinson s disease patients
#MMPMID26621077
Araki K
; Yagi N
; Ikemoto Y
; Yagi H
; Choong CJ
; Hayakawa H
; Beck G
; Sumi H
; Fujimura H
; Moriwaki T
; Nagai Y
; Goto Y
; Mochizuki H
Sci Rep
2015[Dec]; 5
(ä): 17625
PMID26621077
show ga
Lewy bodies (LBs), which mainly consist of ?-synuclein (?-syn), are
neuropathological hallmarks of patients with Parkinson's disease (PD). The fine
structure of LBs is unknown, and LBs cannot be made artificially. Nevertheless,
many studies have described fibrillisation using recombinant ?-syn purified from
E. coli. An extremely fundamental problem is whether the structure of LBs is the
same as that of recombinant amyloid fibrils. Thus, we used synchrotron Fourier
transform infrared micro-spectroscopy (FTIRM) to analyse the fine structure of
LBs in the brain of PD patients. Our results showed a shift in the infrared
spectrum that indicates abundance of a ?-sheet-rich structure in LBs. Also, 2D
infrared mapping of LBs revealed that the content of the ?-sheet structure is
higher in the halo than in the core, and the core contains a large amount of
proteins and lipids.