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10.1371/journal.pntd.0004158 http://scihub22266oqcxt.onion/10.1371/journal.pntd.0004158 C4664471!4664471!26618509     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Negl+Trop+Dis 2015 ; 9 (11): ä Nephropedia Template TP {{tp|p=26618509|t=2015. A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer |pdf=|usr=}}{{26618509}} gab.com Text A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer JO: PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=26618509 #FOAvip Background: Increased availability of Next Generation Sequencing (NGS) techniques allows, for the first time, to distinguish relapses from reinfections in patients with multiple Buruli ulcer (BU) episodes. Methodology: We compared the number and location of single nucleotide polymorphisms (SNPs) identified by genomic screening between four pairs of Mycobacterium ulcerans isolates collected at the time of first diagnosis and at recurrence, derived from a collection of almost 5000 well characterized clinical samples from one BU treatment center in Benin. Principal Findings: The findings suggest that after surgical treatment?without antibiotics?the second episodes were due to relapse rather than reinfection. Since specific antibiotics were introduced for the treatment of BU, the one patient with a culture available from both disease episodes had M. ulcerans isolates with a genomic distance of 20 SNPs, suggesting the patient was most likely reinfected rather than having a relapse. Conclusions: To our knowledge, this study is the first to study recurrences in M. ulcerans using NGS, and to identify exogenous reinfection as causing a recurrence of BU. The occurrence of reinfection highlights the contribution of ongoing exposure to M. ulcerans to disease recurrence, and has implications for vaccine development. Twit Text FOAVip A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer ????PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=26618509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26618509 #FOAvip English Wikipedia <ref>{{Cite pmid|26618509}}</ref> A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer #MMPMID26618509 Eddyani M; Vandelannoote K; Meehan CJ; Bhuju S; Porter JL; Aguiar J; Seemann T; Jarek M; Singh M; Portaels F; Stinear TP; de Jong BC PLoS Negl Trop Dis 2015[Nov]; 9 (11): ä PMID26618509show ga Background: Increased availability of Next Generation Sequencing (NGS) techniques allows, for the first time, to distinguish relapses from reinfections in patients with multiple Buruli ulcer (BU) episodes. Methodology: We compared the number and location of single nucleotide polymorphisms (SNPs) identified by genomic screening between four pairs of Mycobacterium ulcerans isolates collected at the time of first diagnosis and at recurrence, derived from a collection of almost 5000 well characterized clinical samples from one BU treatment center in Benin. Principal Findings: The findings suggest that after surgical treatment?without antibiotics?the second episodes were due to relapse rather than reinfection. Since specific antibiotics were introduced for the treatment of BU, the one patient with a culture available from both disease episodes had M. ulcerans isolates with a genomic distance of 20 SNPs, suggesting the patient was most likely reinfected rather than having a relapse. Conclusions: To our knowledge, this study is the first to study recurrences in M. ulcerans using NGS, and to identify exogenous reinfection as causing a recurrence of BU. The occurrence of reinfection highlights the contribution of ongoing exposure to M. ulcerans to disease recurrence, and has implications for vaccine development. äA Genomic Approach to Resolving Relapse versus Reinfection among Four (epmc).pdf DeepDyve Pubget Overpricing