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10.1073/pnas.1519556112 http://scihub22266oqcxt.onion/10.1073/pnas.1519556112 C4664355!4664355!26561581     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (47): E6496-505 Nephropedia Template TP {{tp|p=26561581|t=2015. Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution |pdf=|usr=}}{{26561581}} gab.com Text Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26561581 #FOAvip A tumor comprising many cells can be compared to a natural population with many individuals. The amount of genetic diversity reflects how it has evolved and can influence its future evolution. We evaluated a single tumor by sequencing or genotyping nearly 300 regions from the tumor. When the data were analyzed by modern population genetic theory, we estimated more than 100 million coding region mutations in this unexceptional tumor. The extreme genetic diversity implies evolution under the non-Darwinian mode. In contrast, under the prevailing view of Darwinian selection, the genetic diversity would be orders of magnitude lower. Because genetic diversity accrues rapidly, a high probability of drug resistance should be heeded, even in the treatment of microscopic tumors. Twit Text FOAVip Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26561581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26561581 #FOAvip English Wikipedia <ref>{{Cite pmid|26561581}}</ref> Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution #MMPMID26561581 Ling S; Hu Z; Yang Z; Yang F; Li Y; Lin P; Chen K; Dong L; Cao L; Tao Y; Hao L; Chen Q; Gong Q; Wu D; Li W; Zhao W; Tian X; Hao C; Hungate EA; Catenacci DVT; Hudson RR; Li WH; Lu X; Wu CI Proc Natl Acad Sci U S A 2015[Nov]; 112 (47): E6496-505 PMID26561581show ga A tumor comprising many cells can be compared to a natural population with many individuals. The amount of genetic diversity reflects how it has evolved and can influence its future evolution. We evaluated a single tumor by sequencing or genotyping nearly 300 regions from the tumor. When the data were analyzed by modern population genetic theory, we estimated more than 100 million coding region mutations in this unexceptional tumor. The extreme genetic diversity implies evolution under the non-Darwinian mode. In contrast, under the prevailing view of Darwinian selection, the genetic diversity would be orders of magnitude lower. Because genetic diversity accrues rapidly, a high probability of drug resistance should be heeded, even in the treatment of microscopic tumors. äExtremely high genetic diversity in a single tumor points to prevalenc(epmc).pdf DeepDyve Pubget Overpricing