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10.1073/pnas.1514152112 http://scihub22266oqcxt.onion/10.1073/pnas.1514152112 C4664344!4664344!26554018     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (47): E6535-43 Nephropedia Template TP {{tp|p=26554018|t=2015. Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis |pdf=|usr=}}{{26554018}} gab.com Text Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26554018 #FOAvip We screened rheumatoid arthritis (RA)-associated copy number variations (CNVs) across the whole genome and identified significant deletion variants encompassing leukocyte-specific protein 1 (LSP1) gene. Functional assays revealed that LSP1, induced by T-cell receptor activation, negatively regulates T-cell migration. Loss of Lsp1 promotes T-cell migration into antigen-instilled tissues and draining lymph nodes in mice with T-cell?dependent chronic inflammation. Moreover, patients with RA show diminished expression of LSP1 in peripheral T cells with increased migratory capacity. To our knowledge, our work is the first to demonstrate how CNVs result in immune dysfunction and a disease phenotype, highlighting the importance of LSP1 CNVs and LSP1 insufficiency in the pathogenesis of RA. Twit Text FOAVip Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26554018 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26554018 #FOAvip English Wikipedia <ref>{{Cite pmid|26554018}}</ref> Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis #MMPMID26554018 Hwang SH; Jung SH; Lee S; Choi S; Yoo SA; Park JH; Hwang D; Shim SC; Sabbagh L; Kim KJ; Park SH; Cho CS; Kim BS; Leng L; Montgomery RR; Bucala R; Chung YJ; Kim WU Proc Natl Acad Sci U S A 2015[Nov]; 112 (47): E6535-43 PMID26554018show ga We screened rheumatoid arthritis (RA)-associated copy number variations (CNVs) across the whole genome and identified significant deletion variants encompassing leukocyte-specific protein 1 (LSP1) gene. Functional assays revealed that LSP1, induced by T-cell receptor activation, negatively regulates T-cell migration. Loss of Lsp1 promotes T-cell migration into antigen-instilled tissues and draining lymph nodes in mice with T-cell?dependent chronic inflammation. Moreover, patients with RA show diminished expression of LSP1 in peripheral T cells with increased migratory capacity. To our knowledge, our work is the first to demonstrate how CNVs result in immune dysfunction and a disease phenotype, highlighting the importance of LSP1 CNVs and LSP1 insufficiency in the pathogenesis of RA. äLeukocyte-specific protein 1 regulates T-cell migration in rheumatoid (epmc).pdf DeepDyve Pubget Overpricing