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10.1371/journal.pone.0138869

http://scihub22266oqcxt.onion/10.1371/journal.pone.0138869
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suck abstract from ncbi


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pmid26619070
      PLoS+One 2015 ; 10 (11 ): e0138869
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  • Multilevel Correlates of Non-Adherence in Kidney Transplant Patients Benefitting from Full Cost Coverage for Immunosuppressives: A Cross-Sectional Study #MMPMID26619070
  • Marsicano EO ; Fernandes NS ; Colugnati FA ; Fernandes NM ; De Geest S ; Sanders-Pinheiro H
  • PLoS One 2015[]; 10 (11 ): e0138869 PMID26619070 show ga
  • BACKGROUND: Adherence is the result of the interaction of the macro, meso, micro, and patient level factors. The macro level includes full coverage of immunosuppressive medications as is the case in Brazil. We studied the correlates of immunosuppressive non-adherence in post kidney transplant patients in the Brazilian health care system. METHODS: Using a cross-sectional design, adherence to immunosuppressives was assessed in a sample of 100 kidney transplant patients using a composite non-adherence score consisting of three methods (self-report [i.e., The Basel Adherence Scale for Assessment of Immunossupressives-BAASIS], collateral report, and immunosuppressive blood levels). Multilevel correlations of non-adherence were assessed (macro, meso, micro and patient level). Univariate and multivariate logistic regression was applied to assess the correlates of non-adherence. RESULTS: Our sample consisted primarily of male (65%), Caucasians (72%) with a mean age of 45.0 ± 13.5 years old, who received grafts from a living donor (89%), with a mean time after transplantation of 72.3 ± 44.4 months. Prevalence of non-adherence was 51%. Family income higher than five reference wages (21.6 vs. 4%; OR 6.46 [1.35-30.89], p = 0.009; patient level), and having access to private health insurance (35.3% vs. 18.4%; OR 2.42 [0.96-6.10], p = 0.04; meso level) were associated with non-adherence in univariate analysis. Only the higher family income variable was retained in the multiple logistic regression model (OR 5.0; IC: 1.01-25.14; p = 0.04). CONCLUSIONS: Higher family income was the only factor that was associated with immunosuppressive non-adherence. In Brazil, lower income recipients benefit from better access to care and coverage of health care costs after transplantation. This is supposed to result in a better immunosuppressive adherence compared to high-income patients who have experienced these benefits continuously.
  • |*Insurance Coverage [MESH]
  • |*Insurance, Health [MESH]
  • |*Kidney Transplantation [MESH]
  • |Adult [MESH]
  • |Cross-Sectional Studies [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Immunosuppressive Agents/*administration & dosage/economics [MESH]
  • |Male [MESH]
  • |Medication Adherence [MESH]
  • |Middle Aged [MESH]


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