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10.1002/sim.6169

http://scihub22266oqcxt.onion/10.1002/sim.6169
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C4663989!4663989!24757049
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suck abstract from ncbi


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pmid24757049      Stat+Med 2014 ; 33 (19): 3241-52
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  • A Modest Proposal for Dropping Poor Arms in Clinical Trials #MMPMID24757049
  • Proschan MA; Dodd LE
  • Stat Med 2014[Aug]; 33 (19): 3241-52 PMID24757049show ga
  • This paper presents a simple procedure for clinical trials comparing several arms to control. Demand for streamlining the evaluation of new treatments has led to Phase III clinical trials with more arms than would have been used in the past. In such a setting, it is reasonable that some arms may not perform as well as an active control. We introduce a simple procedure that takes advantage of negative results in some comparisons to lessen the required strength of evidence for other comparisons. We evaluate properties analytically, and use them to support claims made about multi-arm multi-stage (MAMS) designs.
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