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10.1038/srep17032 http://scihub22266oqcxt.onion/10.1038/srep17032 C4663757!4663757!26616407     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26616407|t=2015. P311 promotes renal fibrosis via TGF?1/Smad signaling |pdf=|usr=}}{{26616407}} gab.com Text P311 promotes renal fibrosis via TGF 1/Smad signaling JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26616407 #FOAvip P311, a gene that was identified in 1993, has been found to have diverse biological functions in processes such as cell proliferation, migration and differentiation. However, its role in fibrosis is unknown. We previously observed that P311 is highly expressed in skin hypertrophic scars. In this study, P311 over-expression was detected in a subset of tubular epithelial cells in clinical biopsy specimens of renal fibrosis; this over-expression, was found concurrent with ?-smooth muscle actin (?-SMA) and transforming growth factor beta1 (TGF?1) expression. Subsequently, these results were verified in a mouse experimental renal fibrosis model induced by unilateral ureteral obstruction. The interstitial deposition of collagen, ?-SMA and TGF-?1 expression, and macrophage infiltration were dramatically decreased when P311 was knocked out. Moreover, TGF?/Smad signaling had a critical effect on the promotion of renal fibrosis by P311. In conclusion, this study demonstrate that P311 plays a key role in renal fibrosis via TGF?1/Smad signaling, which could be a novel target for the management of renal fibrosis. Twit Text FOAVip P311 promotes renal fibrosis via TGF 1/Smad signaling ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26616407 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26616407 #FOAvip English Wikipedia <ref>{{Cite pmid|26616407}}</ref> P311 promotes renal fibrosis via TGF?1/Smad signaling #MMPMID26616407 Yao Z; Yang S; He W; Li L; Xu R; Zhang X; Li H; Zhan R; Sun W; Tan J; Zhou J; Luo G; Wu J Sci Rep 2015[]; 5 (ä): ä PMID26616407show ga P311, a gene that was identified in 1993, has been found to have diverse biological functions in processes such as cell proliferation, migration and differentiation. However, its role in fibrosis is unknown. We previously observed that P311 is highly expressed in skin hypertrophic scars. In this study, P311 over-expression was detected in a subset of tubular epithelial cells in clinical biopsy specimens of renal fibrosis; this over-expression, was found concurrent with ?-smooth muscle actin (?-SMA) and transforming growth factor beta1 (TGF?1) expression. Subsequently, these results were verified in a mouse experimental renal fibrosis model induced by unilateral ureteral obstruction. The interstitial deposition of collagen, ?-SMA and TGF-?1 expression, and macrophage infiltration were dramatically decreased when P311 was knocked out. Moreover, TGF?/Smad signaling had a critical effect on the promotion of renal fibrosis by P311. In conclusion, this study demonstrate that P311 plays a key role in renal fibrosis via TGF?1/Smad signaling, which could be a novel target for the management of renal fibrosis. äP311 promotes renal fibrosis via TGF?1/Smad signaling (epmc).pdf DeepDyve Pubget Overpricing