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10.1186/s13075-015-0800-5 http://scihub22266oqcxt.onion/10.1186/s13075-015-0800-5 C4663738!4663738!26617177     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Res+Ther 2015 ; 17 (ä): ä Nephropedia Template TP {{tp|p=26617177|t=2015. CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis |pdf=|usr=}}{{26617177}} gab.com Text CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26617177 #FOAvip Introduction: Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs). The more severe disease course in ACPA+ RA and differences in treatment outcome between these subpopulations suggest that ACPA+ and ACPA? RA are different disease subsets. The identification of T-helper (Th) cells specifically recognizing citrullinated peptides, combined with the strong association between HLA-DRB1 and ACPA positivity, point toward a pathogenic role of Th cells in ACPA+ RA. In this context we recently identified a potential pathogenic role for CCR6+ Th cells in RA. Therefore, we examined whether Th cell population distributions differ by ACPA status. Methods: We performed a nested matched case?control study including 27 ACPA+ and 27 ACPA? treatment-naive early RA patients matched for disease activity score in 44 joints, presence of rheumatoid factor, sex, age, duration of complaints and presence of erosions. CD4+CD45RO+ (memory) Th cell distribution profiles from these patients were generated based on differential chemokine receptor expression and related with disease duration. Results: ACPA status was not related to differences in total CD4+ T cell or memory Th cell proportions. However, ACPA+ patients had significantly higher proportions of Th cells expressing the chemokine receptors CCR6 and CXCR3. Similar proportions of CCR4+ and CCR10+ Th cells were found. Within the CCR6+ cell population, four Th subpopulations were distinguished based on differential chemokine receptor expression: Th17 (CCR4+CCR10?), Th17.1 (CXCR3+), Th22 (CCR4+CCR10+) and CCR4/CXCR3 double-positive (DP) cells. In particular, higher proportions of Th22 (p?=?0.02), Th17.1 (p?=?0.03) and CCR4/CXCR3 DP (p?=?0.01) cells were present in ACPA+ patients. In contrast, ACPA status was not associated with differences in Th1 (CCR6?CXCR3+; p?=?0.90), Th2 (CCR6?CCR4+; p?=?0.27) and T-regulatory (CD25hiFOXP3+; p?=?0.06) cell proportions. Interestingly, CCR6+ Th cells were inversely correlated with disease duration in ACPA? patients (R2?=??0.35; p?<?0.01) but not in ACPA+ (R2?<?0.01; p?=?0.94) patients. Conclusions: These findings demonstrate that increased peripheral blood CCR6+ Th cells proportions distinguish ACPA+ RA from ACPA? RA. This suggests that CCR6+ Th cells are involved in the differences in disease severity and treatment outcome between ACPA+ and ACPA? RA. Twit Text FOAVip CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26617177 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617177 #FOAvip English Wikipedia <ref>{{Cite pmid|26617177}}</ref> CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis #MMPMID26617177 Paulissen SMJ; van Hamburg JP; Davelaar N; Vroman H; Hazes JMW; de Jong PHP; Lubberts E Arthritis Res Ther 2015[]; 17 (ä): ä PMID26617177show ga Introduction: Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs). The more severe disease course in ACPA+ RA and differences in treatment outcome between these subpopulations suggest that ACPA+ and ACPA? RA are different disease subsets. The identification of T-helper (Th) cells specifically recognizing citrullinated peptides, combined with the strong association between HLA-DRB1 and ACPA positivity, point toward a pathogenic role of Th cells in ACPA+ RA. In this context we recently identified a potential pathogenic role for CCR6+ Th cells in RA. Therefore, we examined whether Th cell population distributions differ by ACPA status. Methods: We performed a nested matched case?control study including 27 ACPA+ and 27 ACPA? treatment-naive early RA patients matched for disease activity score in 44 joints, presence of rheumatoid factor, sex, age, duration of complaints and presence of erosions. CD4+CD45RO+ (memory) Th cell distribution profiles from these patients were generated based on differential chemokine receptor expression and related with disease duration. Results: ACPA status was not related to differences in total CD4+ T cell or memory Th cell proportions. However, ACPA+ patients had significantly higher proportions of Th cells expressing the chemokine receptors CCR6 and CXCR3. Similar proportions of CCR4+ and CCR10+ Th cells were found. Within the CCR6+ cell population, four Th subpopulations were distinguished based on differential chemokine receptor expression: Th17 (CCR4+CCR10?), Th17.1 (CXCR3+), Th22 (CCR4+CCR10+) and CCR4/CXCR3 double-positive (DP) cells. In particular, higher proportions of Th22 (p?=?0.02), Th17.1 (p?=?0.03) and CCR4/CXCR3 DP (p?=?0.01) cells were present in ACPA+ patients. In contrast, ACPA status was not associated with differences in Th1 (CCR6?CXCR3+; p?=?0.90), Th2 (CCR6?CCR4+; p?=?0.27) and T-regulatory (CD25hiFOXP3+; p?=?0.06) cell proportions. Interestingly, CCR6+ Th cells were inversely correlated with disease duration in ACPA? patients (R2?=??0.35; p? äCCR6+ Th cell populations distinguish ACPA positive from ACPA negative(epmc).pdf DeepDyve Pubget Overpricing