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10.3389/fimmu.2015.00600 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00600 C4663633!4663633 !26648933     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26648933 &cmd=llinks): Failed to open stream: HTTP request failed! 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Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins |pdf=|usr=}}{{26648933 }} gab.com Text Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26648933 #FOAvip The central nervous system (CNS) of patients with multiple sclerosis (MS) is the site where disease pathology is evident. Damaged CNS tissue is commonly associated with immune cell infiltration. This infiltrate often includes B cells that are found in multiple locations throughout the CNS, including the cerebrospinal fluid (CSF), parenchyma, and the meninges, frequently forming tertiary lymphoid structures in the latter. Several groups, including our own, have shown that B cells from distinct locations within the MS CNS are clonally related and display the characteristics of an antigen-driven response. However, the antigen(s) driving this response have yet to be conclusively defined. To explore the antigen specificity of the MS B cell response, we produced recombinant human immunoglobulin (rIgG) from a series of expanded B cell clones that we isolated from the CNS tissue of six MS brains. The specificity of these MS-derived rIgG and control rIgG derived from non-MS tissues was then examined using multiple methodologies that included testing individual candidate antigens, screening with high-throughput antigen arrays and evaluating binding to CNS-derived cell lines. We report that while several MS-derived rIgG recognized particular antigens, including neurofilament light and a protocadherin isoform, none were unique to MS, as non-MS-derived rIgG used as controls invariably displayed similar binding specificities. We conclude that while MS CNS resident B cells display the characteristics of an antigen-driven B cell response, the antigen(s) driving this response remain at large. Twit Text FOAVip Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26648933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26648933 #FOAvip English Wikipedia <ref>{{Cite pmid|26648933 }}</ref> Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins #MMPMID26648933 Willis SN ; Stathopoulos P ; Chastre A ; Compton SD ; Hafler DA ; O'Connor KC Front Immunol 2015[]; 6 (ä): 600 PMID26648933 show ga The central nervous system (CNS) of patients with multiple sclerosis (MS) is the site where disease pathology is evident. Damaged CNS tissue is commonly associated with immune cell infiltration. This infiltrate often includes B cells that are found in multiple locations throughout the CNS, including the cerebrospinal fluid (CSF), parenchyma, and the meninges, frequently forming tertiary lymphoid structures in the latter. Several groups, including our own, have shown that B cells from distinct locations within the MS CNS are clonally related and display the characteristics of an antigen-driven response. However, the antigen(s) driving this response have yet to be conclusively defined. To explore the antigen specificity of the MS B cell response, we produced recombinant human immunoglobulin (rIgG) from a series of expanded B cell clones that we isolated from the CNS tissue of six MS brains. The specificity of these MS-derived rIgG and control rIgG derived from non-MS tissues was then examined using multiple methodologies that included testing individual candidate antigens, screening with high-throughput antigen arrays and evaluating binding to CNS-derived cell lines. We report that while several MS-derived rIgG recognized particular antigens, including neurofilament light and a protocadherin isoform, none were unique to MS, as non-MS-derived rIgG used as controls invariably displayed similar binding specificities. We conclude that while MS CNS resident B cells display the characteristics of an antigen-driven B cell response, the antigen(s) driving this response remain at large. äInvestigating the Antigen Specificity of Multiple Sclerosis Central Ne(epmc).pdf DeepDyve Pubget Overpricing