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2015 ; 7
(27
): 2774-80
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Portal vein thrombosis, mortality and hepatic decompensation in patients with
cirrhosis: A meta-analysis
#MMPMID26644821
Stine JG
; Shah PM
; Cornella SL
; Rudnick SR
; Ghabril MS
; Stukenborg GJ
; Northup PG
World J Hepatol
2015[Nov]; 7
(27
): 2774-80
PMID26644821
show ga
AIM: To determine the clinical impact of portal vein thrombosis in terms of both
mortality and hepatic decompensations (variceal hemorrhage, ascites,
portosystemic encephalopathy) in adult patients with cirrhosis. METHODS: We
identified original articles reported through February 2015 in MEDLINE, Scopus,
Science Citation Index, AMED, the Cochrane Library, and relevant examples
available in the grey literature. Two independent reviewers screened all
citations for inclusion criteria and extracted summary data. Random effects odds
ratios were calculated to obtain aggregate estimates of effect size across
included studies, with 95%CI. RESULTS: A total of 226 citations were identified
and reviewed, and 3 studies with 2436 participants were included in the
meta-analysis of summary effect. Patients with portal vein thrombosis had an
increased risk of mortality (OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein
thrombosis was associated with an increased risk of ascites (OR = 2.52, 95%CI:
1.63-3.89, P < 0.001). There was insufficient data available to determine the
pooled effect on other markers of decompensation including gastroesophageal
variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis
appears to increase mortality and ascites, however, the relatively small number
of included studies limits more generalizable conclusions. More trials with a
direct comparison group are needed.