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10.4254/wjh.v7.i27.2729 http://scihub22266oqcxt.onion/10.4254/wjh.v7.i27.2729 C4663392!4663392!26644816     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Hepatol 2015 ; 7 (27): 2729-39 Nephropedia Template TP {{tp|p=26644816|t=2015. Clinical significance of hepatitis B surface antigen mutants |pdf=|usr=}}{{26644816}} gab.com Text Clinical significance of hepatitis B surface antigen mutants JO: World J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26644816 #FOAvip Hepatitis B virus (HBV) infection is a major public health problem in many countries, with nearly 300 million people worldwide carrying HBV chronic infection and over 1 million deaths per year due to cirrhosis and liver cancer. Several hepatitis B surface antigen (HBsAg) mutations have been described, most frequently due to a single amino acid substitution and seldom to a nucleotide deletion. The majority of mutations are located in the S region, but they have also been found in the pre-S1 and pre-S2 regions. Single amino acid substitutions in the major hydrophilic region of HBsAg, called the ?a? determinant, have been associated with immune escape and the consequent failure of HBV vaccination and HBsAg detection, whereas deletions in the pre-S1 or pre-S2 regions have been associated with the development of hepatocellular carcinoma. This review article will focus on the HBsAg mutants and their biological and clinical implications. Twit Text FOAVip Clinical significance of hepatitis B surface antigen mutants ????World J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26644816 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26644816 #FOAvip English Wikipedia <ref>{{Cite pmid|26644816}}</ref> Clinical significance of hepatitis B surface antigen mutants #MMPMID26644816 Coppola N; Onorato L; Minichini C; Di Caprio G; Starace M; Sagnelli C; Sagnelli E World J Hepatol 2015[Nov]; 7 (27): 2729-39 PMID26644816show ga Hepatitis B virus (HBV) infection is a major public health problem in many countries, with nearly 300 million people worldwide carrying HBV chronic infection and over 1 million deaths per year due to cirrhosis and liver cancer. Several hepatitis B surface antigen (HBsAg) mutations have been described, most frequently due to a single amino acid substitution and seldom to a nucleotide deletion. The majority of mutations are located in the S region, but they have also been found in the pre-S1 and pre-S2 regions. Single amino acid substitutions in the major hydrophilic region of HBsAg, called the ?a? determinant, have been associated with immune escape and the consequent failure of HBV vaccination and HBsAg detection, whereas deletions in the pre-S1 or pre-S2 regions have been associated with the development of hepatocellular carcinoma. This review article will focus on the HBsAg mutants and their biological and clinical implications. äClinical significance of hepatitis B surface antigen mutants (epmc).pdf DeepDyve Pubget Overpricing