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10.1155/2016/1073140 http://scihub22266oqcxt.onion/10.1155/2016/1073140 C4663346!4663346!26649044     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cells+Int 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=26649044|t=2016. Extracellular Vesicles: Evolving Factors in Stem Cell Biology |pdf=|usr=}}{{26649044}} gab.com Text Extracellular Vesicles: Evolving Factors in Stem Cell Biology JO: Stem Cells Int http://www.kidney.de/pget.php?&tw=1&pmid=26649044 #FOAvip Stem cells are proposed to continuously secrete trophic factors that potentially serve as mediators of autocrine and paracrine activities, associated with reprogramming of the tumor microenvironment, tissue regeneration, and repair. Hitherto, significant efforts have been made to understand the level of underlying paracrine activities influenced by stem cell secreted trophic factors, as little is known about these interactions. Recent findings, however, elucidate this role by reporting the effects of stem cell derived extracellular vesicles (EVs) that mimic the phenotypes of the cells from which they originate. Exchange of genetic information utilizing persistent bidirectional communication mediated by stem cell-EVs could regulate stemness, self-renewal, and differentiation in stem cells and their subpopulations. This review therefore discusses stem cell-EVs as evolving communication factors in stem cell biology, focusing on how they regulate cell fates by inducing persistent and prolonged genetic reprogramming of resident cells in a paracrine fashion. In addition, we address the role of stem cell-secreted vesicles in shaping the tumor microenvironment and immunomodulation and in their ability to stimulate endogenous repair processes during tissue damage. Collectively, these functions ensure an enormous potential for future therapies. Twit Text FOAVip Extracellular Vesicles: Evolving Factors in Stem Cell Biology ????Stem Cells Int http://www.kidney.de/pget.php?&tw=1&pmid=26649044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26649044 #FOAvip English Wikipedia <ref>{{Cite pmid|26649044}}</ref> Extracellular Vesicles: Evolving Factors in Stem Cell Biology #MMPMID26649044 Nawaz M; Fatima F; Vallabhaneni KC; Penfornis P; Valadi H; Ekström K; Kholia S; Whitt JD; Fernandes JD; Pochampally R; Squire JA; Camussi G Stem Cells Int 2016[]; 2016 (ä): ä PMID26649044show ga Stem cells are proposed to continuously secrete trophic factors that potentially serve as mediators of autocrine and paracrine activities, associated with reprogramming of the tumor microenvironment, tissue regeneration, and repair. Hitherto, significant efforts have been made to understand the level of underlying paracrine activities influenced by stem cell secreted trophic factors, as little is known about these interactions. Recent findings, however, elucidate this role by reporting the effects of stem cell derived extracellular vesicles (EVs) that mimic the phenotypes of the cells from which they originate. Exchange of genetic information utilizing persistent bidirectional communication mediated by stem cell-EVs could regulate stemness, self-renewal, and differentiation in stem cells and their subpopulations. This review therefore discusses stem cell-EVs as evolving communication factors in stem cell biology, focusing on how they regulate cell fates by inducing persistent and prolonged genetic reprogramming of resident cells in a paracrine fashion. In addition, we address the role of stem cell-secreted vesicles in shaping the tumor microenvironment and immunomodulation and in their ability to stimulate endogenous repair processes during tissue damage. Collectively, these functions ensure an enormous potential for future therapies. äExtracellular Vesicles: Evolving Factors in Stem Cell Biology (epmc).pdf DeepDyve Pubget Overpricing