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10.1097/JTO.0000000000000363

http://scihub22266oqcxt.onion/10.1097/JTO.0000000000000363
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suck abstract from ncbi


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pmid25393794
      J+Thorac+Oncol 2014 ; 9 (12 ): 1810-5
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  • Clinical characteristics and outcomes for patients with thymic carcinoma: evaluation of Masaoka staging #MMPMID25393794
  • Litvak AM ; Woo K ; Hayes S ; Huang J ; Rimner A ; Sima CS ; Moreira AL ; Tsukazan M ; Riely GJ
  • J Thorac Oncol 2014[Dec]; 9 (12 ): 1810-5 PMID25393794 show ga
  • BACKGROUND: Thymic carcinomas are rare cancers with limited data regarding outcomes, particularly for those patients with advanced disease. METHODS: We identified patients with thymic carcinomas diagnosed between 1993 and 2012. Patient characteristics, recurrence-free survival (RFS), and overall survival (OS) were analyzed. RESULTS: One hundred twenty-one patients with thymic carcinomas were identified. Higher Masaoka stage was associated with worse OS and RFS (5-year OS of 100%, 81%, 51%, 24%, and 17% for stage I, II, III, IVa, and IVb respectively, p < 0.001 and 5-year RFS of 80%, 28%, and 7% for stage I/II, III, and IV respectively, p < 0.001). Patients with stage IVb lymph node (LN) only disease had a better 5-year OS as compared with patients with distant metastasis (24% versus 7%, p = 0.025). Of the 61 patients with stage IVb disease, 22 of 29 patients (76%) with LN-only disease underwent curative intent resection versus 3 of 32 patients (9%) with distant metastasis. Twenty-two patients with LN involvement were treated with multimodality therapy. Three (14%) remain free of disease with long-term follow-up (range, 3.4+ years- to 6.8+ years). CONCLUSIONS: We describe the clinical features of a large series of patients with thymic carcinoma in North America. The Masaoka staging system effectively prognosticated OS and RFS. Patients with stage IVb LN-only disease had significantly better OS as compared with patients with distant metastasis with a subset of patients sustaining long-term RFS with multimodality therapy. If validated, these data would support a revised staging system with subclassification of stage IVb disease into two groups.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Child [MESH]
  • |Disease-Free Survival [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Neoplasm Staging [MESH]
  • |Retrospective Studies [MESH]
  • |Survival Analysis [MESH]
  • |Thymoma/diagnosis/*pathology/therapy [MESH]
  • |Thymus Neoplasms/*pathology/therapy [MESH]
  • |Treatment Outcome [MESH]


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