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10.1007/s12020-015-0614-x http://scihub22266oqcxt.onion/10.1007/s12020-015-0614-x C4662713!4662713!25989955     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Endocrine 2015 ; 50 (3): 633-42 Nephropedia Template TP {{tp|p=25989955|t=2015. Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader?Willi syndrome |pdf=|usr=}}{{25989955}} gab.com Text Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader Willi syndrome JO: Endocrine http://www.kidney.de/pget.php?&tw=1&pmid=25989955 #FOAvip Prader?Willi syndrome (PWS) is characterized by a switch from failure to thrive to excessive weight gain and hyperphagia in early childhood. Hyperghrelinemia may be involved in the underlying mechanisms of the switch. The purpose of this study is to evaluate acylated ghrelin (AG) and unacylated ghrelin (UAG) levels in PWS and investigate their associations with hyperphagia. This is a cross-sectional clinical study conducted in three PWS expert centers in the Netherlands and France. Levels of AG and UAG and the AG/UAG ratio were determined in 138 patients with PWS (0.2?29.4 years) and compared with 50 age-matched obese subjects (4.3?16.9 years) and 39 healthy controls (0.8?28.6 years). AEBSF was used to inhibit deacylation of AG. As a group, PWS patients had higher AG but similar UAG levels as healthy controls (AG 129.1 vs 82.4 pg/ml, p = 0.016; UAG 135.3 vs 157.3 pg/ml, resp.), resulting in a significantly higher AG/UAG ratio (1.00 vs 0.61, p = 0.001, resp.). Obese subjects had significantly lower AG and UAG levels than PWS and controls (40.3 and 35.3 pg/ml, resp.), but also a high AG/UAG ratio (1.16). The reason for the higher AG/UAG ratio in PWS and obese was, however, completely different, as PWS had a high AG and obese a very low UAG. PWS patients without weight gain or hyperphagia had a similar AG/UAG ratio as age-matched controls, in contrast to those with weight gain and/or hyperphagia who had an elevated AG/UAG ratio. The switch to excessive weight gain in PWS seems to coincide with an increase in the AG/UAG ratio, even prior to the start of hyperphagia.Electronic supplementary material: The online version of this article (doi:10.1007/s12020-015-0614-x) contains supplementary material, which is available to authorized users. Twit Text FOAVip Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader Willi syndrome ????Endocrine http://www.kidney.de/pget.php?&tw=1&pmid=25989955 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25989955 #FOAvip English Wikipedia <ref>{{Cite pmid|25989955}}</ref> Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader?Willi syndrome #MMPMID25989955 Kuppens RJ; Dične G; Bakker NE; Molinas C; Faye S; Nicolino M; Bernoux D; Delhanty PJD; van der Lely AJ; Allas S; Julien M; Delale T; Tauber M; Hokken-Koelega ACS Endocrine 2015[]; 50 (3): 633-42 PMID25989955show ga Prader?Willi syndrome (PWS) is characterized by a switch from failure to thrive to excessive weight gain and hyperphagia in early childhood. Hyperghrelinemia may be involved in the underlying mechanisms of the switch. The purpose of this study is to evaluate acylated ghrelin (AG) and unacylated ghrelin (UAG) levels in PWS and investigate their associations with hyperphagia. This is a cross-sectional clinical study conducted in three PWS expert centers in the Netherlands and France. Levels of AG and UAG and the AG/UAG ratio were determined in 138 patients with PWS (0.2?29.4 years) and compared with 50 age-matched obese subjects (4.3?16.9 years) and 39 healthy controls (0.8?28.6 years). AEBSF was used to inhibit deacylation of AG. As a group, PWS patients had higher AG but similar UAG levels as healthy controls (AG 129.1 vs 82.4 pg/ml, p = 0.016; UAG 135.3 vs 157.3 pg/ml, resp.), resulting in a significantly higher AG/UAG ratio (1.00 vs 0.61, p = 0.001, resp.). Obese subjects had significantly lower AG and UAG levels than PWS and controls (40.3 and 35.3 pg/ml, resp.), but also a high AG/UAG ratio (1.16). The reason for the higher AG/UAG ratio in PWS and obese was, however, completely different, as PWS had a high AG and obese a very low UAG. PWS patients without weight gain or hyperphagia had a similar AG/UAG ratio as age-matched controls, in contrast to those with weight gain and/or hyperphagia who had an elevated AG/UAG ratio. The switch to excessive weight gain in PWS seems to coincide with an increase in the AG/UAG ratio, even prior to the start of hyperphagia.Electronic supplementary material: The online version of this article (doi:10.1007/s12020-015-0614-x) contains supplementary material, which is available to authorized users. äElevated ratio of acylated to unacylated ghrelin in children and young(epmc).pdf DeepDyve Pubget Overpricing