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10.4137/EBO.S27693 http://scihub22266oqcxt.onion/10.4137/EBO.S27693 C4662427!4662427!26640363     free     free     free       Evol+Bioinform+Online 2015 ; 11 (ä): 253-61 Nephropedia Template TP {{tp|p=26640363|t=2015. Segmenting the Human Genome into Isochores |pdf=|usr=}}{{26640363}} gab.com Text Segmenting the Human Genome into Isochores JO: Evol Bioinform Online http://www.kidney.de/pget.php?&tw=1&pmid=26640363 #FOAvip The human genome is a mosaic of isochores, which are long (>200 kb) DNA sequences that are fairly homogeneous in base composition and can be assigned to five families comprising 33%?59% of GC composition. Although the compartmentalized organization of the mammalian genome has been investigated for more than 40 years, no satisfactory automatic procedure for segmenting the genome into isochores is available so far. We present a critical discussion of the currently available methods and a new approach called isoSegmenter which allows segmenting the genome into isochores in a fast and completely automatic manner. This approach relies on two types of experimentally defined parameters, the compositional boundaries of isochore families and an optimal window size of 100 kb. The approach represents an improvement over the existing methods, is ideally suited for investigating long-range features of sequenced and assembled genomes, and is publicly available at https://github.com/bunop/isoSegmenter. Twit Text FOAVip Segmenting the Human Genome into Isochores ????Evol Bioinform Online http://www.kidney.de/pget.php?&tw=1&pmid=26640363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26640363 #FOAvip English Wikipedia <ref>{{Cite pmid|26640363}}</ref> Segmenting the Human Genome into Isochores #MMPMID26640363 Cozzi P; Milanesi L; Bernardi G Evol Bioinform Online 2015[]; 11 (ä): 253-61 PMID26640363show ga The human genome is a mosaic of isochores, which are long (>200 kb) DNA sequences that are fairly homogeneous in base composition and can be assigned to five families comprising 33%?59% of GC composition. Although the compartmentalized organization of the mammalian genome has been investigated for more than 40 years, no satisfactory automatic procedure for segmenting the genome into isochores is available so far. We present a critical discussion of the currently available methods and a new approach called isoSegmenter which allows segmenting the genome into isochores in a fast and completely automatic manner. This approach relies on two types of experimentally defined parameters, the compositional boundaries of isochore families and an optimal window size of 100 kb. The approach represents an improvement over the existing methods, is ideally suited for investigating long-range features of sequenced and assembled genomes, and is publicly available at https://github.com/bunop/isoSegmenter. äSegmenting the Human Genome into Isochores (epmc).pdf DeepDyve Pubget Overpricing