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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biomed+Res
2015 ; 29
(6
): 437-44
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English Wikipedia
Platelets in hemostasis and thrombosis: Novel mechanisms of
fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave
of hemostasis
#MMPMID26541706
Hou Y
; Carrim N
; Wang Y
; Gallant RC
; Marshall A
; Ni H
J Biomed Res
2015[Oct]; 29
(6
): 437-44
PMID26541706
show ga
Platelets are small anucleate cells generated from megakaryocytes in the bone
marrow. Although platelet generation, maturation, and clearance are still not
fully understood, significant progress has been made in the last 1-2 decades. In
blood circulation, platelets can quickly adhere and aggregate at sites of
vascular injury, forming the platelet plug (i.e. the first wave of hemostasis).
Activated platelets can also provide negatively charged phosphatidylserinerich
membrane surface that enhances cell-based thrombin generation, which facilitates
blood coagulation (i.e. the second wave of hemostasis). Platelets therefore play
central roles in hemostasis. However, the same process of hemostasis may also
cause thrombosis and vessel occlusion, which are the most common mechanisms
leading to heart attack and stroke following ruptured atherosclerotic lesions. In
this review, we will introduce the classical mechanisms and newly discovered
pathways of platelets in hemostasis and thrombosis, including
fibrinogen-independent platelet aggregation and thrombosis, and the plasma
fibronectin-mediated "protein wave" of hemostasis that precedes the classical
first wave of hemostasis. Furthermore, we briefly discuss the roles of platelets
in inflammation and atherosclerosis and the potential strategies to control
atherothrombosis.