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2015 ; 35
(5
): 439-43
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The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A
Complementary, or Alternative, Viewpoint?
#MMPMID26573546
Goilav B
; Putterman C
Semin Nephrol
2015[Sep]; 35
(5
): 439-43
PMID26573546
show ga
Kidney disease, or lupus nephritis, is the organ involvement that is most closely
associated with specific autoantibodies in patients with SLE. The concept of
anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis
emerged ~50 years ago, and has been a topic of debate ever since. This article
focuses on the description of the renal sub-cellular targets of nephritogenic
autoantibodies and offers a counter-point opinion to the article by Pedersen et
al. In addition, we provide an overview of some of the mechanisms by which
anti-DNA antibodies bind to their renal targets and the pathogenic relevance to
clinical nephritis.