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10.3390/ijms161126063 http://scihub22266oqcxt.onion/10.3390/ijms161126063 C4661921!4661921!26610488     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2015 ; 16 (11): 27956-66 Nephropedia Template TP {{tp|p=26610488|t=2015. The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33 |pdf=|usr=}}{{26610488}} gab.com Text The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26610488 #FOAvip IL-33 is a new member of the IL-1 family cytokines, which is expressed by different types of immune cells and non-immune cells. IL-33 is constitutively expressed in the nucleus, where it can act as a transcriptional regulator. So far, no direct target for nuclear IL-33 has been identified, and the regulation of IL-33 nuclear function remains largely unclear. Here, we report that the transcription of type 2 inflammatory cytokine IL-13 is positively regulated by nuclear IL-33. IL-33 can directly bind to the conserved non-coding sequence (CNS) before the translation initiation site in the IL13 gene locus. Moreover, IL-33 nuclear function and stability are regulated by the enzyme ubiquitin-specific protease 17 (USP17) through deubiquitination of IL-33 both at the K48 and at the K63 sites. Our data suggest that IL13 gene transcription can be directly activated by nuclear IL-33, which is negatively regulated by the deubiquitinase USP17. Twit Text FOAVip The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26610488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26610488 #FOAvip English Wikipedia <ref>{{Cite pmid|26610488}}</ref> The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33 #MMPMID26610488 Ni Y; Tao L; Chen C; Song H; Li Z; Gao Y; Nie J; Piccioni M; Shi G; Li B Int J Mol Sci 2015[Nov]; 16 (11): 27956-66 PMID26610488show ga IL-33 is a new member of the IL-1 family cytokines, which is expressed by different types of immune cells and non-immune cells. IL-33 is constitutively expressed in the nucleus, where it can act as a transcriptional regulator. So far, no direct target for nuclear IL-33 has been identified, and the regulation of IL-33 nuclear function remains largely unclear. Here, we report that the transcription of type 2 inflammatory cytokine IL-13 is positively regulated by nuclear IL-33. IL-33 can directly bind to the conserved non-coding sequence (CNS) before the translation initiation site in the IL13 gene locus. Moreover, IL-33 nuclear function and stability are regulated by the enzyme ubiquitin-specific protease 17 (USP17) through deubiquitination of IL-33 both at the K48 and at the K63 sites. Our data suggest that IL13 gene transcription can be directly activated by nuclear IL-33, which is negatively regulated by the deubiquitinase USP17. äThe Deubiquitinase USP17 Regulates the Stability and Nuclear Function (epmc).pdf DeepDyve Pubget Overpricing