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2015 ; 5
(ä): 17150
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Add-on Protective Effect of Pentoxifylline in Advanced Chronic Kidney Disease
Treated with Renin-Angiotensin-Aldosterone System Blockade - A Nationwide
Database Analysis
#MMPMID26612282
Kuo KL
; Hung SC
; Liu JS
; Chang YK
; Hsu CC
; Tarng DC
Sci Rep
2015[Nov]; 5
(ä): 17150
PMID26612282
show ga
A combination therapy of pentoxifylline with an angiotensin converting enzyme
inhibitor (ACEI) or an angiotensin II receptor blocker (ARB) decreased
proteinuria or glomerular filtration rate decline in early chronic kidney disease
(CKD). Whether adding pentoxifylline to ACEI/ARB provides additional benefits on
outcome is unclear in CKD stage 5 patients who have not yet received dialysis
(CKD 5?ND). A prospective cohort study was conducted based on the Taiwan National
Health Insurance Research Database. From January 1, 2000 to June 30, 2009, we
enrolled 14,117?CKD 5?ND with serum creatinine levels >6?mg/dL and hematocrit
levels <28% and who have been treated with ACEI/ARB. All patients were divided
into pentoxifylline users and nonusers. Patient follow-up took place until
dialysis, death before initiation of dialysis or December 31, 2009. Finally,
9,867 patients (69.9%) required long-term dialysis and 2,805 (19.9%) died before
dialysis. After propensity score-matching, use of pentoxifylline was associated
with a lower risk for long-term dialysis or death in ACEI/ARB users (HR, 0.94;
95% CI, 0.90-0.99) or ARB users (HR, 0.91; 95% CI, 0.85-0.97). In conclusion,
pentoxifylline exhibited a protective effect in reducing the risk for the
composite outcome of long-term dialysis or death in ACEI/ARB treated CKD 5?ND.
|*Renal Dialysis
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
[MESH]