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10.1074/jbc.M115.677401

http://scihub22266oqcxt.onion/10.1074/jbc.M115.677401
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C4661416!4661416!26378235
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suck abstract from ncbi


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pmid26378235      J+Biol+Chem 2015 ; 290 (48): 29045-50
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  • The Responses of Hyperglycemic Dividing Mesangial Cells to Heparin Are Mediated by the Non-reducing Terminal Trisaccharide* #MMPMID26378235
  • Wang CP; Hascall VC; Zhang F; Linhardt RJ; Abbadi A; Wang A
  • J Biol Chem 2015[Nov]; 290 (48): 29045-50 PMID26378235show ga
  • Background: Heparin prevents intracellular hyaluronan synthesis and subsequent autophagy in hyperglycemic dividing mesangial cells.Results: The non-reducing terminal trisaccharide of heparin is sufficient for this response.Conclusion: This heparin trisaccharide motif is exposed by the mammalian heparanase and is recognized by a receptor on dividing cells.Significance: The trisaccharide does not have the anti-coagulant properties of heparin.
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