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10.1074/jbc.M115.669226

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suck abstract from ncbi


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pmid26468283      J+Biol+Chem 2015 ; 290 (48): 28977-87
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  • Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles* #MMPMID26468283
  • Haapasalo K; van Kessel K; Nissilä E; Metso J; Johansson T; Miettinen S; Varjosalo M; Kirveskari J; Kuusela P; Chroni A; Jauhiainen M; van Strijp J; Jokiranta TS
  • J Biol Chem 2015[Nov]; 290 (48): 28977-87 PMID26468283show ga
  • Background: Factor H is the main complement alternative pathway regulator in plasma.Results: Factor H binds to apoE leading to reduced complement activity against HDL particles.Conclusion: Interaction of factor H with HDL particles is involved in complement regulation in plasma.Significance: Complement regulation on HDL particles by factor H could be involved in disease processes caused by alternative pathway dysregulation.
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