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10.1074/jbc.M115.668244 http://scihub22266oqcxt.onion/10.1074/jbc.M115.668244 C4661405!4661405!26438819     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2015 ; 290 (48): 28915-31 Nephropedia Template TP {{tp|p=26438819|t=2015. p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase* |pdf=|usr=}}{{26438819}} gab.com Text p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26438819 #FOAvip Background: The role of phosphorylation for regulating the Rac1 GEF PREX2 is not understood.Results: PAK phosphorylation of PREX2 downstream of PIP3 and G?? reduces PREX2 GEF activity.Conclusion: Second messengers can initiate negative feedback to decrease Rac1 activation through PAK phosphorylation of PREX2.Significance: PAK negative regulation of GEFs could represent a broadly utilized mechanism to attenuate Rac1 activation and its outputs. Twit Text FOAVip p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26438819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26438819 #FOAvip English Wikipedia <ref>{{Cite pmid|26438819}}</ref> p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase* #MMPMID26438819 Barrows D; Schoenfeld SM; Hodakoski C; Silkov A; Honig B; Couvillon A; Shymanets A; Nürnberg B; Asara JM; Parsons R J Biol Chem 2015[Nov]; 290 (48): 28915-31 PMID26438819show ga Background: The role of phosphorylation for regulating the Rac1 GEF PREX2 is not understood.Results: PAK phosphorylation of PREX2 downstream of PIP3 and G?? reduces PREX2 GEF activity.Conclusion: Second messengers can initiate negative feedback to decrease Rac1 activation through PAK phosphorylation of PREX2.Significance: PAK negative regulation of GEFs could represent a broadly utilized mechanism to attenuate Rac1 activation and its outputs. äp21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Prot(epmc).pdf DeepDyve Pubget Overpricing