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10.1074/jbc.M115.681429

http://scihub22266oqcxt.onion/10.1074/jbc.M115.681429
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C4661384!4661384!26433011
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suck abstract from ncbi

pmid26433011      J+Biol+Chem 2015 ; 290 (48): 28683-96
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  • The Role of Phospholipase D in Regulated Exocytosis* #MMPMID26433011
  • Rogasevskaia TP; Coorssen JR
  • J Biol Chem 2015[Nov]; 290 (48): 28683-96 PMID26433011show ga
  • Background: Phospholipase D (PLD)-derived phosphatidic acid (PA) is suggested to function in exocytosis.Results: PLD activity on the plasma membrane was higher than on vesicles. PLD inhibitors suppressed some fusion parameters, but blockade of PA did not affect fusion.Conclusion: PLD-derived PA has modulatory rather than direct effects on fusion.Significance: Identifying critical mechanistic components may enable interventions to target diseases affecting exocytosis.
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