The Role of Phospholipase D in Regulated Exocytosis* #MMPMID26433011
Rogasevskaia TP; Coorssen JR
J Biol Chem 2015[Nov]; 290 (48): 28683-96 PMID26433011show ga
Background: Phospholipase D (PLD)-derived phosphatidic acid (PA) is suggested to function in exocytosis.Results: PLD activity on the plasma membrane was higher than on vesicles. PLD inhibitors suppressed some fusion parameters, but blockade of PA did not affect fusion.Conclusion: PLD-derived PA has modulatory rather than direct effects on fusion.Significance: Identifying critical mechanistic components may enable interventions to target diseases affecting exocytosis.