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10.1074/jbc.M115.661611

http://scihub22266oqcxt.onion/10.1074/jbc.M115.661611
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C4661383!4661383!26429911
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suck abstract from ncbi


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pmid26429911      J+Biol+Chem 2015 ; 290 (48): 28675-82
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  • Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells* #MMPMID26429911
  • Luo X; Nie J; Wang S; Chen Z; Chen W; Li D; Hu H; Li B
  • J Biol Chem 2015[Nov]; 290 (48): 28675-82 PMID26429911show ga
  • Background: PARP-1 has importance in the immune system.Results: Poly(ADP-ribosyl)ation of FOXP3 mediated by PARP-1 destabilizes FOXP3 and negatively regulates the suppressive activity of Treg cells.Conclusion: PARP-1 negatively regulates Treg function via FOXP3 poly(ADP-ribosyl)ation.Significance: This study helps the development of PARP-1 inhibitors to prevent autoimmune diseases.
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