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10.1074/jbc.M115.661553

http://scihub22266oqcxt.onion/10.1074/jbc.M115.661553
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C4661380!4661380!26416890
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suck abstract from ncbi


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pmid26416890      J+Biol+Chem 2015 ; 290 (48): 28643-63
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  • The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer*? #MMPMID26416890
  • Daou S; Hammond-Martel I; Mashtalir N; Barbour H; Gagnon J; Iannantuono NVG; Nkwe NS; Motorina A; Pak H; Yu H; Wurtele H; Milot E; Mallette FA; Carbone M; Affar EB
  • J Biol Chem 2015[Nov]; 290 (48): 28643-63 PMID26416890show ga
  • Background: The relevance of ASXL2 to the function of the histone H2A deubiquitinase BAP1 remains unknown.Results: ASXL2 promotes the assembly by BAP1 of a composite ubiquitin-binding interface (CUBI) required for DUB activity and coordination of cell proliferation.Conclusion: Cancer-associated mutations of BAP1 disrupt BAP1-ASXL2 interaction and function.Significance: We provide novel insights into BAP1 tumor suppressor function.
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