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10.1074/jbc.M115.685305

http://scihub22266oqcxt.onion/10.1074/jbc.M115.685305
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C4661378!4661378!26370085
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suck abstract from ncbi


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pmid26370085      J+Biol+Chem 2015 ; 290 (48): 28631-41
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  • Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)*? #MMPMID26370085
  • VanSchouwen B; Selvaratnam R; Giri R; Lorenz R; Herberg FW; Kim C; Melacini G
  • J Biol Chem 2015[Nov]; 290 (48): 28631-41 PMID26370085show ga
  • Background: Protein kinase G (PKG) is selectively activated by cGMP, but the mechanism of cGMP-versus-cAMP selectivity is not fully understood.Results: cAMP-bound PKG exists in a dynamic exchange between three states, inactive, active, and a partially autoinhibited state, which results in partial agonism.Conclusion: Partial agonism contributes to cGMP-versus-cAMP selectivity.Significance: The cGMP-versus-cAMP selectivity controls the cross-talk between cGMP- and cAMP-dependent signaling pathways.
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