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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2015 ; 290 (48): 28631-41 Nephropedia Template TP
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Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)*? #MMPMID26370085
VanSchouwen B; Selvaratnam R; Giri R; Lorenz R; Herberg FW; Kim C; Melacini G
J Biol Chem 2015[Nov]; 290 (48): 28631-41 PMID26370085show ga
Background: Protein kinase G (PKG) is selectively activated by cGMP, but the mechanism of cGMP-versus-cAMP selectivity is not fully understood.Results: cAMP-bound PKG exists in a dynamic exchange between three states, inactive, active, and a partially autoinhibited state, which results in partial agonism.Conclusion: Partial agonism contributes to cGMP-versus-cAMP selectivity.Significance: The cGMP-versus-cAMP selectivity controls the cross-talk between cGMP- and cAMP-dependent signaling pathways.