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10.1007/s10555-015-9595-8 http://scihub22266oqcxt.onion/10.1007/s10555-015-9595-8 C4661189!4661189!26350886     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Metastasis+Rev 2015 ; 34 (4): 753-64 Nephropedia Template TP {{tp|p=26350886|t=2015. EPLIN: a fundamental actin regulator in cancer metastasis?|pdf=|usr=}}{{26350886}} gab.com Text EPLIN: a fundamental actin regulator in cancer metastasis JO: Cancer Metastasis Rev http://www.kidney.de/pget.php?&tw=1&pmid=26350886 #FOAvip Treatment of malignant disease is of paramount importance in modern medicine. In 2012, it was estimated that 162,000 people died from cancer in the UK which illustrates a fundamental problem. Traditional treatments for cancer have various drawbacks, and this creates a considerable need for specific, molecular targets to overcome cancer spread. Epithelial protein lost in neoplasm (EPLIN) is an actin-associated molecule which has been implicated in the development and progression of various cancers including breast, prostate, oesophageal and lung where EPLIN expression is frequently lost as the cancer progresses. EPLIN is important in the regulation of actin dynamics and has multiple associations at epithelial cells junctions. Thus, EPLIN loss in cancer may have significant effects on cancer cell migration and invasion, increasing metastatic potential. Overexpression of EPLIN has proved to be an effective tool for manipulating cancerous traits such as reducing cell growth and cell motility and rendering cells less invasive illustrating the therapeutic potential of EPLIN. Here, we review the current state of knowledge of EPLIN, highlighting EPLIN involvement in regulating cytoskeletal dynamics, signalling pathways and implications in cancer and metastasis. Twit Text FOAVip EPLIN: a fundamental actin regulator in cancer metastasis ????Cancer Metastasis Rev http://www.kidney.de/pget.php?&tw=1&pmid=26350886 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26350886 #FOAvip English Wikipedia <ref>{{Cite pmid|26350886}}</ref> EPLIN: a fundamental actin regulator in cancer metastasis? #MMPMID26350886 Collins RJ; Jiang WG; Hargest R; Mason MD; Sanders AJ Cancer Metastasis Rev 2015[]; 34 (4): 753-64 PMID26350886show ga Treatment of malignant disease is of paramount importance in modern medicine. In 2012, it was estimated that 162,000 people died from cancer in the UK which illustrates a fundamental problem. Traditional treatments for cancer have various drawbacks, and this creates a considerable need for specific, molecular targets to overcome cancer spread. Epithelial protein lost in neoplasm (EPLIN) is an actin-associated molecule which has been implicated in the development and progression of various cancers including breast, prostate, oesophageal and lung where EPLIN expression is frequently lost as the cancer progresses. EPLIN is important in the regulation of actin dynamics and has multiple associations at epithelial cells junctions. Thus, EPLIN loss in cancer may have significant effects on cancer cell migration and invasion, increasing metastatic potential. Overexpression of EPLIN has proved to be an effective tool for manipulating cancerous traits such as reducing cell growth and cell motility and rendering cells less invasive illustrating the therapeutic potential of EPLIN. Here, we review the current state of knowledge of EPLIN, highlighting EPLIN involvement in regulating cytoskeletal dynamics, signalling pathways and implications in cancer and metastasis. äEPLIN: a fundamental actin regulator in cancer metastasis?(epmc).pdf DeepDyve Pubget Overpricing