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10.1182/blood-2015-07-533588 http://scihub22266oqcxt.onion/10.1182/blood-2015-07-533588 C4661168!4661168!26468230     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2015 ; 126 (22): 2443-51 Nephropedia Template TP {{tp|p=26468230|t=2015. The hematopoietic stem cell niche in homeostasis and disease |pdf=|usr=}}{{26468230}} gab.com Text The hematopoietic stem cell niche in homeostasis and disease JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=26468230 #FOAvip The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that they generate. We highlight emerging data that stem cell niches in the bone marrow are not static but instead are responsive to environmental stimuli. Finally, we review recent data showing that hematopoietic niches are altered in certain hematopoietic malignancies, and we discuss how these alterations might contribute to disease pathogenesis. Twit Text FOAVip The hematopoietic stem cell niche in homeostasis and disease ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=26468230 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26468230 #FOAvip English Wikipedia <ref>{{Cite pmid|26468230}}</ref> The hematopoietic stem cell niche in homeostasis and disease #MMPMID26468230 Calvi LM; Link DC Blood 2015[Nov]; 126 (22): 2443-51 PMID26468230show ga The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that they generate. We highlight emerging data that stem cell niches in the bone marrow are not static but instead are responsive to environmental stimuli. Finally, we review recent data showing that hematopoietic niches are altered in certain hematopoietic malignancies, and we discuss how these alterations might contribute to disease pathogenesis. äThe hematopoietic stem cell niche in homeostasis and disease (epmc).pdf DeepDyve Pubget Overpricing