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2014 ; 7
(4
): 393-6
Nephropedia Template TP
gab.com Text
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English Wikipedia
The evaluation of the activity of medicinal remedies of plant and animal origin
on the regeneration of the earthworms tail segments
#MMPMID26692755
Bybin VA
; Stom DI
Pharmacognosy Res
2014[Oct]; 7
(4
): 393-6
PMID26692755
show ga
Now, in the global community there is enough hard recommendation to replace the
vertebrate test animals into simpler organisms at the development, testing, and
evaluation of the quality pharmaceuticals. The feature of planarian to regenerate
in new individual planarian from a piece, which is only 1/7 of the original
animal, allowed to create the alternative methods of testing of drugs, dietary
supplements, water quality, influence of electromagnetic fields, and other
radiations. The tests on planarian can replace the ones that are held today on
mammals. However, the lacks of the bioassays based on the planarian regeneration
are the need for complex and expensive video equipment for recording the regrowth
of worms' body, the difficulties of culturing of flatworms and fairly long period
of response. These difficulties can be avoided by using another group of the
worms of type Annelida. The new individual can be fully recovered only from the
front half of the body in many species of earthworms. Thus, the influence of the
pharmaceuticals from earthworms, mummy, and Orthilia secunda on the ability of
earthworms to regenerate lost tail segments has been investigated. The relations
of the activity of preparations tested with doses and the time of the storage
have been revealed. The principal possibility of applicability of the test
reaction studied as a way to evaluate the effects and quality of remedies based
on medicinal plants and earthworms has been shown.