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10.1155/2015/415024 http://scihub22266oqcxt.onion/10.1155/2015/415024 C4660030!4660030!26640324     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26640324|t=2015. Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis |pdf=|usr=}}{{26640324}} gab.com Text Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26640324 #FOAvip Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm where severity as well as treatment complexity is mainly attributed to a long lasting disease and presence of bone marrow stroma alterations as evidenced by myelofibrosis, neoangiogenesis, and osteosclerosis. While recent understanding of mutations role in hematopoietic cells provides an explanation for pathological myeloproliferation, functional involvement of stromal cells in the disease pathogenesis remains poorly understood. The current dogma is that stromal changes are secondary to the cytokine ?storm? produced by the hematopoietic clone cells. However, despite therapies targeting the myeloproliferation-sustaining clones, PMF is still regarded as an incurable disease except for patients, who are successful recipients of allogeneic stem cell transplantation. Although the clinical benefits of these inhibitors have been correlated with a marked reduction in serum proinflammatory cytokines produced by the hematopoietic clones, further demonstrating the importance of inflammation in the pathological process, these treatments do not address the role of the altered bone marrow stroma in the pathological process. In this review, we propose hypotheses suggesting that the stroma is inflammatory-imprinted by clonal hematopoietic cells up to a point where it becomes ?independent? of hematopoietic cell stimulation, resulting in an inflammatory vicious circle requiring combined stroma targeted therapies. Twit Text FOAVip Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26640324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26640324 #FOAvip English Wikipedia <ref>{{Cite pmid|26640324}}</ref> Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis #MMPMID26640324 Desterke C; Martinaud C; Ruzehaji N; Le Bousse-Kerdilès MC Mediators Inflamm 2015[]; 2015 (ä): ä PMID26640324show ga Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm where severity as well as treatment complexity is mainly attributed to a long lasting disease and presence of bone marrow stroma alterations as evidenced by myelofibrosis, neoangiogenesis, and osteosclerosis. While recent understanding of mutations role in hematopoietic cells provides an explanation for pathological myeloproliferation, functional involvement of stromal cells in the disease pathogenesis remains poorly understood. The current dogma is that stromal changes are secondary to the cytokine ?storm? produced by the hematopoietic clone cells. However, despite therapies targeting the myeloproliferation-sustaining clones, PMF is still regarded as an incurable disease except for patients, who are successful recipients of allogeneic stem cell transplantation. Although the clinical benefits of these inhibitors have been correlated with a marked reduction in serum proinflammatory cytokines produced by the hematopoietic clones, further demonstrating the importance of inflammation in the pathological process, these treatments do not address the role of the altered bone marrow stroma in the pathological process. In this review, we propose hypotheses suggesting that the stroma is inflammatory-imprinted by clonal hematopoietic cells up to a point where it becomes ?independent? of hematopoietic cell stimulation, resulting in an inflammatory vicious circle requiring combined stroma targeted therapies. äInflammation as a Keystone of Bone Marrow Stroma Alterations in Primar(epmc).pdf DeepDyve Pubget Overpricing