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2015 ; 2015
(ä): 817592
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Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose
Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis
#MMPMID26640735
Wakabayashi T
; Sasaki N
; Chinen N
; Suzuki Y
Case Rep Rheumatol
2015[]; 2015
(ä): 817592
PMID26640735
show ga
A 17-year-old boy with juvenile dermatomyositis presented with typical skin
symptoms, mild myositis, and bilateral lower limb calcinosis. His skin and muscle
symptoms responded to treatment with prednisolone and azathioprine. However,
calcinosis did not improve, and the patient had a limited range of knee joint
motion and resultant disturbance of daily activities. Cimetidine was combined
with intermittent administration of high-dose etidronate, leading to marked
improvement of both subcutaneous and muscular calcinosis with no skeletal adverse
reactions during a long treatment period exceeding 5 years. As a result, the
range of knee joint motion has increased and performance of daily activities has
improved.