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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Immunol
2015 ; 35
(8
): 696-726
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Primary Immunodeficiency Diseases: an Update on the Classification from the
International Union of Immunological Societies Expert Committee for Primary
Immunodeficiency 2015
#MMPMID26482257
Picard C
; Al-Herz W
; Bousfiha A
; Casanova JL
; Chatila T
; Conley ME
; Cunningham-Rundles C
; Etzioni A
; Holland SM
; Klein C
; Nonoyama S
; Ochs HD
; Oksenhendler E
; Puck JM
; Sullivan KE
; Tang ML
; Franco JL
; Gaspar HB
J Clin Immunol
2015[Nov]; 35
(8
): 696-726
PMID26482257
show ga
We report the updated classification of primary immunodeficiencies compiled by
the Primary Immunodeficiency Expert Committee (PID EC) of the International Union
of Immunological Societies (IUIS). In the two years since the previous version,
34 new gene defects are reported in this updated version. For each disorder, the
key clinical and laboratory features are provided. In this new version we
continue to see the increasing overlap between immunodeficiency, as manifested by
infection and/or malignancy, and immune dysregulation, as manifested by
auto-inflammation, auto-immunity, and/or allergy. There is also an increased
number of genetic defects that lead to susceptibility to specific organisms which
reflects the finely tuned nature of immune defense systems. This classification
is the most up to date catalogue of all known and published primary
immunodeficiencies and acts as a current reference of the knowledge of these
conditions and is an important aid for the genetic and molecular diagnosis of
patients with these rare diseases.
|Autoimmune Diseases/genetics/*immunology
[MESH]
|Carcinogenesis/genetics/immunology
[MESH]
|Consensus Development Conferences as Topic
[MESH]